Objective: To assess the fine-needle aspiration cytology (FNAC) and histopathological results of thyroid nodules sized 4 cm or larger with benign cytology.
Study Design: Analytical study.
Place And Duration Of Study: Health Science University Umraniye Training and Research Hospital, Istanbul, Turkey.
Methodology: Patients with thyroid nodule size 4 cm. or larger and benign FNAC results were included in the study. All patients' age, gender, size of nodule, results of FNAC, types of surgery and histopathological results of thyroid specimen were extracted from patients' files.
Results: Out of 720 patients, who underwent thyroidectomy between January 2009 and January 2018, 310 patients with a benign FNAC results, between the ages of 18 and 78 years, with nodule diameters ranging from 4 to 8.4 cm were included in the study. Of these 310 patients, 243 (78.4%) were females and 67 (21.6%) were males. In the final histopathological examination, thyroid carcinoma was detected in five of the cases (1.6%).
Conclusion: The risk of malignancy in 4 cm and larger thyroid nodules with benign FNAC was as much as expected in other benign nodules.
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http://dx.doi.org/10.29271/jcpsp.2018.09.703 | DOI Listing |
Prostate Cancer
December 2024
Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, Al-Neelain University, Khartoum, Sudan.
Prostate cancer is the most common noncutaneous malignancy among men worldwide, including in Sudan, where it represents a significant public health challenge. CD147, a transmembrane glycoprotein implicated in tumor progression, invasion, and metastasis, has shown potential as a prognostic biomarker in various cancers. This retrospective case-control study aimed to evaluate CD147 expression in prostate adenocarcinoma among Sudanese men and its association with tumor grade.
View Article and Find Full Text PDFInt J Surg Case Rep
December 2024
Gastroenterology Department, Al Ahli Hospital, Hebron 90200, Palestine.
Introduction: Esophageal leiomyoma is the most common benign submucosal mesenchymal tumor of the esophagus, typically asymptomatic but can cause symptoms such as dysphagia, chest pain, or regurgitation when large. Diagnosis is often incidental, confirmed by imaging techniques like computed tomography (CT) and endoscopic ultrasound (EUS), with surgical enucleation being the standard treatment.
Presentation Of Case: A 28-year-old male presented with a one-year history of persistent epigastric discomfort and gastroesophageal reflux disease (GERD) symptoms unresponsive to proton pump inhibitors.
Sci Rep
December 2024
School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China.
Platelets possess cancer-induced reprogramming properties, thereby contributing to RNA profile alterations and further cancer progression, while the former is considered a promising biosource for cancer detection. Hence, tumor-educated platelets (TEP) are considered a prospective novel method for early breast cancer (BC) screening. Our study integrated the data from 276 patients with untreated BC, 95 with benign disease controls, 214 healthy controls, and 2 who underwent mastectomy in Chinese and European cohorts to develop a 10-biomarker diagnostic model.
View Article and Find Full Text PDFDiseases
November 2024
Gastroenterology, Endocrinology, Metabolism and Clinical Infectiology, University Hospital Giessen and Marburg, Philipp University of Marburg, Baldingerstraße, 35037 Marburg, Germany.
Purpose: To evaluate the ability of acoustic radiation force impulse (ARFI) elastography in differentiating benign from malignant etiologies of splenomegaly based on differences in splenic stiffness.
Materials And Methods: Between September 2020 and November 2022, we evaluated 40 patients with splenomegaly-defined by a splenic long axis greater than 13 cm and/or a short axis greater than 6 cm, without visible focal or infiltrative mass lesions-using abdominal ultrasound at our university hospital. Each patient also underwent a standardized ARFI elastographic assessment of the enlarged spleen, with data collected prospectively.
Eur Arch Otorhinolaryngol
December 2024
Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Ospedale di Circolo, Varese, Italy.
Background: Artificial intelligence (AI) demonstrates high potential when applied to radiomic analysis of magnetic resonance imaging (MRI) to discriminate sinonasal tumors. This can enhance diagnostic suspicion beyond visual assessment alone and prior to biopsy, leading to expedite the diagnostic timeline and the treatment planning. The aim of the present work is to evaluate the current advancements and accuracy of this technology in this domain.
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