Cross Talk from Tubules to Glomeruli.

Toxicol Pathol

2 Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Published: December 2018

Tubular injury sensitizes glomeruli to injury. We review potential mechanisms of this tubuloglomerular cross talk. In the same nephron, tubular injury can cause stenosis of the glomerulotubular junction and finally result in atubular glomeruli. Tubular injury also affects glomerular filtration function through tubuloglomerular feedback. Progenitor cells, that is, parietal epithelial cells and renin positive cells, can be involved in repair of injured glomeruli and also may be modulated by tubular injury. Loss of nephrons induces additional workload and stress on remaining nephrons. Hypoxia and activation of the renin-angiotensin-aldosterone system induced by tubular injury also modulate tubuloglomerular cross talk. Therefore, effective therapies in chronic kidney disease may need to aim to interrupt this deleterious tubuloglomerular cross talk.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693660PMC
http://dx.doi.org/10.1177/0192623318796784DOI Listing

Publication Analysis

Top Keywords

tubular injury
20
cross talk
16
tubuloglomerular cross
12
glomeruli tubular
8
injury
6
tubular
5
cross
4
talk tubules
4
glomeruli
4
tubules glomeruli
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!