AI Article Synopsis
- A new metal-free reduction system uses HSe produced from Se/DMF/HO as the active reducing agent.
- This system utilizes water as a safe and eco-friendly hydrogen donor.
- It demonstrates high selectivity and effectiveness in reducing α,β-unsaturated ketones and alkynes, highlighting its potential for practical applications in organic chemistry.
Article Abstract
A novel metal-free reduction system, in which HSe (or HSe) produced in situ from Se/DMF/HO acts as the active reducing species, has been developed. By using water as an inexpensive, safe, and environmentally friendly surrogate as the hydrogen donor, this new reduction system incorporating Se/DMF/HO displayed high selectivity and good activity in the reduction of α,β-unsaturated ketones and alkynes. Therefore, this reduction system has great potential to be a general and practical reduction methodology in organic transformation.
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| http://dx.doi.org/10.1021/acs.orglett.8b02244 | DOI Listing |
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