AI Article Synopsis
- The study focuses on extracting and understanding the chemical components found in the pinecones of the Pinus griffithii species.
- Researchers used chromatography techniques and spectroscopy to separate, purify, and identify the compounds.
- They discovered two new abietane-type diterpenes along with seven previously known compounds, marking the first isolation of all these substances from this specific plant.
Article Abstract
Objective: To study the chemical constituents from the pinecones of Pinus griffithii.
Methods: The constituents were separated and purified with chromatographic methods,and spectroscopic analysis were employed for structural elucidation.
Results: Two new abietane type diterpenes and seven known compounds were isolated from the pinecones of Pinus griffithii,and were identified as 15-hydroxy-7α-methoxy-abiet-8,11,13-trien-18-oic acid( 1),7α,13-dihydroxy-podocarpane-8,11,13-trien-18-oic acid( 2),7,12,13,15-tetrahydroxy-abiet-8( 14)-en-18-oic acid( 3),7β,15-dihydroxy-abiet-8,11,13-trien-18-oic acid( 4),18-norabiet-8,11,13-trien-4,7,15-triol( 5),15-hydroxy-abiet-8,11,13-trien-18-oic acid( 6),7α-hydroxy-15-methoxy-abiet-8,11,13-trien-18-oic acid( 7),7α-hydroxypodocarpen-8( 14)-en-13-one-18-oic acid( 8), oleanolic acid( 9).
Conclusion: Compounds 1,2 are the new abietane type diterpene,and all compounds are isolated from this plant for first time.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Phlecarinatones H-N: Abietane-type diterpenoids from Phlegmariurus carinatus with proliferative inhibitory effect on U251 glioblastoma cells.
Phytochemistry
December 2024
Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, Jiangxi, 341000, China; Jiangxi Provincal Key Laboratory of Tissue Engineering, 2024SSY06291, Gannan Medical University, Ganzhou, Jiangxi, 341000, China; School of Pharmacy, Nanchang Medical College, Nanchang, Jiangxi, 330052, China. Electronic address:
Thirteen abietane-type diterpenoids, including seven previously undescribed compounds and six known analogs, were isolated from the root and aerial parts of Phlegmariurus carinatus. Their structures were elucidated by comprehensive spectroscopic data analysis (UV, IR, NMR, and HRESIMS) and quantum chemical calculations (calculated ECD or C NMR). Notably, these compounds exhibited high structural diversity.
View Article and Find Full Text PDFTanshinone I inhibits the functions of T lymphocytes and exerts therapeutic effects on delayed-type hypersensitivity reaction via blocking STATs signaling pathways.
Eur J Pharmacol
December 2024
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China; Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. Electronic address:
Delayed-type hypersensitivity (DTH) reactions are a kind of chronic inflammatory diseases initiated by antigens and antigen-specific T cells. Currently, the therapy of DTH reactions is limited by the poor curative effects and serious adverse reactions of existing agents. In this study, we investigated the regulatory effects of tanshinone Ⅰ, a natural compound isolated from Salvia miltiorrhiza, on the functions of multiple immune cells and its therapeutic effects on DNFB-induced DTH reaction, and then explored its immunosuppressive mechanisms.
View Article and Find Full Text PDFent-Abietane-type lactones with anti-inflammatory activity from Euphorbia helioscopia.
Phytochemistry
January 2025
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 222 South Tianshui Road, Lanzhou, 730000, People's Republic of China. Electronic address:
Article Synopsis
- Six new compounds called Euphohelinodes D-I (1-6), which are ent-abietane lactones, were discovered from the plant E. helioscopia, known for its anti-inflammatory properties.
- The structures of these compounds were analyzed using advanced techniques like spectroscopic data, X-ray diffraction, and ECD analysis.
- The most effective compound, euphohelinode H (5), reduced nitric oxide production in inflammatory cells and inhibited key enzymes linked to inflammation via the NF-κB signaling pathway, showing potential for treating inflammatory conditions.
Evaluation of the Role of Tanshinone I in an In Vitro System of Charcot-Marie-Tooth Disease Type 2N.
Int J Mol Sci
October 2024
School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China.
Charcot-Marie-Tooth disease type 2N (CMT2N) is an inherited nerve disorder caused by mutations in the alanyl-tRNA synthetase (AlaRS) gene, resulting in muscle weakness and sensory issues. Currently, there is no cure for CMT2N. Here, we found that all five AlaRS mutations in the aminoacylation domain can interact with neuropilin-1 (Nrp1), which is consistent with our previous findings.
View Article and Find Full Text PDFDiscovery of Tetrahydro Tanshinone I as a Naturally Occurring Covalent -Inhibitor Against Gut Microbial Bile Salt Hydrolases.
J Agric Food Chem
October 2024
Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Gut microbial bile salt hydrolases (gmBSHs), an important class of bacteria-produced cysteine hydrolases, play a crucial role in bile acid metabolism. Modulating the total gmBSH activity is a feasible way for ameliorating some metabolic diseases including colorectal cancer, type 2 diabetes, and obesity. This study reported the discovery and characterization of a botanical compound as a covalent -inhibitor of gmBSHs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!