AI Article Synopsis
- Sjögren's syndrome is a slow-progressing systemic disorder that can cause significant disability and has seen important recent research developments in its pathogenesis, diagnosis, and treatment.
- Key insights include the roles of miRNA, gut microbiota, and different immune responses in understanding how the disease develops.
- Advances in diagnostic techniques, particularly the use of salivary gland ultrasonography and histology, alongside updates on clinical manifestations and future therapies, are also highlighted.
Article Abstract
Sjögren's syndrome is a complex and potentially disabling slow progressive, systemic disorder. During the last twelve months several original and important contributions have been published on the pathogenesis, diagnosis and therapy of the disease. This review, following the others of this series is aimed at summarising some of the most significant studies that have been recently published. Regarding the pathogenesis, we will specifically focus on novel insights on miRNA, gut microbiota, adaptive and innate autoimmunity and animal models. Concerning novelties in pSS diagnosis, we will focus on salivary gland ultrasonography and histology. Finally, we will conclude with an update of the clinical manifestations of the disease and with an overview of the future therapies.
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