This supplement was funded by Novo Nordisk. McGill has received grants and personal fees from Novo Nordisk; grants from AstraZeneca, Novartis, Lexicon, and Pfizer; and personal fees from Intarcia, Boehringer-Ingelheim, Janssen, Mannkind, Bayer, and Merck.
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| http://dx.doi.org/10.18553/jmcp.2018.24.9-a.s3 | DOI Listing |
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Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity.
N Engl J Med
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From the Department of Cardiovascular Disease, Saint Luke's Mid America Heart Institute, University of Missouri-Kansas City School of Medicine, Kansas City (M.N.K.); Novo Nordisk, Søborg (S.Z.A., S.R., G.K.H., M.L.L., D.V.M., M.B.T.), and the Department of Cardiology, Herlev-Gentofte Hospital, University of Copenhagen, Herlev (M. Schou) - both in Denmark; the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (B.A.B.); Baylor Scott and White Research Institute, Dallas (J.B.); the Department of Medicine, University of Mississippi, Jackson (J.B.); Diabetes Research Centre, University of Leicester, and National Institute for Health and Care Research Leicester Biomedical Research Centre (M.D.), Leicester, the Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester (F.Z.A.), and the School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow (M.C.P.) - all in the United Kingdom; the Department of Cardiovascular Medicine and Section on Geriatrics and Gerontology, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.); the Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S.); the Division of Cardiac Surgery, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto (S.V.), and University of Alberta, Edmonton (J.E.) - both in Canada; the College of Health and Medicine, the Australian National University, Canberra, ACT, Australia (W.A.); Max Super Specialty Hospital, New Delhi, India (V.C.); the Section of Cardiology, Department of Medicine, Sahlgrenska University Hospital-Ostra, Gothenburg, Sweden (M.F.); the Department of General Internal Medicine 3, Kawasaki Medical School, Okayama, Japan (H.I.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); the Institute for Clinical and Experimental Medicine, Prague, Czech Republic (V.M.); the Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Hospital Clínico Universitario de Valencia, INCLIVA, Universidad de Valencia, and CIBER (Centro de Investigación Biomédica en Red) Cardiovascular, Valencia, Spain (J.N.); Instituto de Cardiologia J.F. Cabral, Corrientes, Argentina (E.P.); ASST (Azienda Sociosanitaria Territoriale) Papa Giovanni XXIII, Bergamo, Italy (M. Senni); John Hopkins Hospital, Baltimore (K.S.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (P.V.M.); Medical University of Graz, Graz, Austria (D.L.); and Cardiology and Angiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany (D.W.).
Article Synopsis
- Heart failure with preserved ejection fraction (HFpEF) is more common in individuals with obesity and currently lacks approved treatments targeting this specific condition.
- A study involving 529 obese patients with HFpEF tested the weekly administration of semaglutide against a placebo over a 52-week period, measuring changes in symptoms, body weight, and physical activity.
- Results showed that semaglutide significantly improved symptoms (KCCQ-CSS score increase of 16.6 vs. 8.7 for placebo), reduced body weight (-13.3% vs. -2.6%), and enhanced walking distance (21.5 m vs. 1.2 m), with additional benefits noted in inflammation levels. *
Predictors of weight loss outcomes in obesity care: results of the national ACTION study.
BMC Public Health
October 2019
KJT Group, Inc., Honeoye Falls, NY, USA.
Background: A key objective of this study was to examine obesity care attitudes and behaviors of people with obesity (PwO) and determine independent factors associated with a self-reported sustained weight loss success outcome.
Methods: An online survey was conducted in 2015 among 3008 U.S.
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