Background: Vancomycin resistant enterococci (VRE) occur with enhanced frequency in hospitalised patients. This study elucidates the prevalence of VRE on admission among surgical intensive care unit (SICU) patients, whether these patients are at special risk for VRE acquisition and which risk factors support this process.
Methods: Patients admitted to SICUs of the University Hospital Münster were examined during August-October 2017. VRE screening was performed within 48 h after admission and directly prior to discharge of patients. In parallel risk factors were recorded to estimate their effect on VRE acquisition during SICU stay.
Results: In total, 374 patients (68% male) with a median age of 66 years were admitted to one of the SICUs during the investigation period. Of all, 336 patients (89.8%) were screened on admission and 268 (71.7%) on discharge. Nine patients were admitted with previously known VRE colonisation. Twelve (3.6%) further patients were VRE positive on admission. During ICU stay, eight (3.0%) additional patients turned out to be VRE colonised. Risk factors found to be significantly associated with VRE acquisition were median length of stay on the ICU (14 vs. 3 days; = 0.01), long-term dialysis (12.5% vs. 2.0% of patients; = 0.05), and antibiotic treatment with flucloxacillin (28.6% vs. 7.2% of patients; = 0.01) or piperacillin/tazobactam (57.1% vs. 26.6% of patients; = 0.01).
Conclusions: SICU patients are not at special risk for VRE acquisition. Previous stay on a SICU should therefore not be considered as specific risk factor for VRE colonisation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108103 | PMC |
| http://dx.doi.org/10.1186/s13756-018-0394-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Oral vancomycin use and incidence of vancomycin-resistant enterococci: time-series analysis.
Antimicrob Resist Infect Control
December 2024
Department of Infectious Disease, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Article Synopsis
- Vancomycin exposure is linked to an increased risk of colonization by vancomycin-resistant enterococci (VRE), particularly through oral administration, which was examined in this retrospective study.
- The study analyzed data from a large hospital in South Korea over a ten-year period and found a significant correlation between oral vancomycin use and the incidence of hospital-acquired VRE.
- The findings underscore the importance of implementing antibiotic stewardship strategies to manage oral vancomycin use and prevent the spread of VRE in healthcare settings.
The transmission risk of multidrug-resistant organisms between hospital patients and their pets - a case-control study, Germany, 2019 to 2022.
Euro Surveill
September 2024
Institute of Hygiene and Environmental Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
BackgroundCarriage of multidrug-resistant organisms (MDROs) in humans constitutes an important public health concern. Cross-transmission of bacteria between animals and humans has been demonstrated before.AimOur aim was to quantify the risk factor 'pet ownership' for MDRO colonisation in hospital patients.
View Article and Find Full Text PDFGut colonization with multidrug resistant organisms in the intensive care unit: a systematic review and meta-analysis.
Crit Care
June 2024
Division of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY, USA.
Background: Gut colonization with multidrug-resistant organisms (MDRO) frequently precedes infection among patients in the intensive care unit (ICU), although the dynamics of colonization are not completely understood. We performed a systematic review and meta-analysis of ICU studies which described the cumulative incidence and rates of MDRO gut acquisition.
Methods: We systematically searched PubMed, Embase, and Web of Science for studies published from 2010 to 2023 reporting on gut acquisition of MDRO in the ICU.
Article Synopsis
- VRE infections are a major healthcare challenge due to their complex transmission dynamics, which involve patient colonization and spread through various healthcare settings.
- Whole genome sequencing (WGS) was used to analyze 352 clinical and 891 rectal screening VRE isolates, revealing that the majority (87.3%) of VRE infections were acquired through rectal carriage.
- The study identified significant genetic relatedness among isolates and hotspots for VRE transmission, emphasizing the importance of WGS in infection control and highlighting the impact on patient outcomes, including ICU admissions and mortality rates.
Bloodstream infections and multidrug resistant bacteria acquisition among burns patients in Australia and New Zealand: A registry-based study.
Burns
August 2024
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Introduction: This study interrogates infection related data in the Burns Registry of Australia and New Zealand (BRANZ), to examine associations of multi-drug resistant organisms (MDROs) and blood stream infection (BSI).
Methods: Data between July 2016 and June 2021 were analysed to determine prevalence, risk factors and outcomes associated with BSIs and MDROs: Methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), carbapenem-resistant Pseudomonas spp. (CRP), and carbapenem-resistant Enterobacter (CRE).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!