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http://dx.doi.org/10.3389/fpls.2018.01090 | DOI Listing |
Front Endocrinol (Lausanne)
January 2025
Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD, United States.
Recombinant human IGF-1 is used to treat severe primary IGF-1 deficiency, but this treatment requires twice-daily injection, often does not fully correct the growth deficit, and has important off-target effects. We therefore sought to target IGF-1 to growth plate cartilage by generating fusion proteins combining IGF-1 with single-chain human antibody fragments that target matrilin-3, a cartilage matrix protein. We previously showed that this cartilage-targeting IGF-1 fusion protein (CV1574-1) promoted growth plate function in a GH-deficient (lit) mouse model.
View Article and Find Full Text PDFJ Health Monit
December 2024
Robert Koch Institute, Department for Epidemiology and Health Monitoring, Berlin, Germany.
Natl Sci Rev
January 2025
Scientific Director, Institute of Neuroscience, Chinese Academy of Sciences, China.
Lancet Infect Dis
January 2025
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Antimicrobial resistance continues to be a growing threat globally, specifically in health-care settings in which antimicrobial-resistant pathogens cause a substantial proportion of health-care-associated infections (HAIs). Next-generation sequencing (NGS) and the analysis of the data produced therein (ie, bioinformatics) represent an opportunity to enhance our capacity to address these threats. The 3rd Geneva Infection Prevention and Control Think Tank brought together experts to identify gaps, propose solutions, and set priorities for the use of NGS for HAIs and antimicrobial-resistant pathogens.
View Article and Find Full Text PDFBiophys Rev
December 2024
Rutgers, the State University of New Jersey, Piscataway, NJ USA.
This editorial introduces the contents of Volume 16, Issue 6 of , the official journal of the International Union for Pure and Applied Biophysics (IUPAB). Highlights of the Issue include an invited review article by David Alsteens, the winner of the 2024 Michèle Auger Award for Young Scientists' Independent Research and a Special Issue Focus involving a series of articles based on topics addressed at the 7th Nanoengineering for Mechanobiology Symposium 2024. The broad scope of articles and the geographically widespread locations of the contributing authors of these and other reviews in the Issue mirror the goals of IUPAB, namely to organize worldwide advancements, co-operation, communication, and education in biophysics.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!