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Detection of early relapse in multiple myeloma patients.
Cell Div
January 2025
Babak Myeloma Group, Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Background: Multiple myeloma (MM) represents the second most common hematological malignancy characterized by the infiltration of the bone marrow by plasma cells that produce monoclonal immunoglobulin. While the quality and length of life of MM patients have significantly increased, MM remains a hard-to-treat disease; almost all patients relapse. As MM is highly heterogenous, patients relapse at different times.
View Article and Find Full Text PDFAn evaporite sequence from ancient brine recorded in Bennu samples.
Nature
January 2025
Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ, USA.
Evaporation or freezing of water-rich fluids with dilute concentrations of dissolved salts can produce brines, as observed in closed basins on Earth and detected by remote sensing on icy bodies in the outer Solar System. The mineralogical evolution of these brines is well understood in regard to terrestrial environments, but poorly constrained for extraterrestrial systems owing to a lack of direct sampling. Here we report the occurrence of salt minerals in samples of the asteroid (101955) Bennu returned by the OSIRIS-REx mission.
View Article and Find Full Text PDFExpanding the chemical coverage of polar compounds in water analysis by coupling supercritical fluid with hydrophilic interaction chromatography high-resolution mass spectrometry.
Anal Chim Acta
March 2025
Van't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands; Centre for Analytical Sciences Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands. Electronic address:
Background: Persistent and mobile organic compounds (PMOC) are of great concern for water quality and human health. The recent improvement and availability of high-resolution mass spectrometry in combination with liquid chromatography have widely expanded the potential of analytical workflows for their detection and quantitation in water. Given their high polarity, the detection of some PMOC requires alternative techniques to reversed-phase chromatography, such as hydrophilic interaction liquid chromatography (HILIC) and supercritical fluid chromatography (SFC).
View Article and Find Full Text PDFA novel interval sparse evolutionary algorithm for efficient spectral variable selection.
Anal Chim Acta
March 2025
School of Automation, Central South University, 410083, Changsha, China. Electronic address:
In spectral analysis, selecting the right spectral variables is crucial for effective modeling. It reduces data dimensionality, removes irrelevant wavelength points, and improves both the generalization ability and computational efficiency of the model. However, the number of available samples often falls short of the total possible combinations of wavelengths, making variable selection a non-deterministic polynomial-time (NP) hard optimization problem.
View Article and Find Full Text PDFOptical time-lapse microscopy for rapid assessment of microbial quality in hygroscopic food samples.
J Microbiol Methods
January 2025
National Food Institute, Technical University of Denmark, Henrik Dams Allé, 2800 Kgs. Lyngby, Denmark. Electronic address:
In the food industry, time-to-result is crucial for faster release of products, minimising recalls, mitigation of microbial contamination problems and, ultimately, food safety. Carrageenan is isolated from red seaweed (Rhodophyta) and applied in various foods and beverages as a gelling, thickening, texturing, or stabilizing agent due to its hygroscopic properties. Currently, the standard industry plate count method entails a one-hundred-fold dilution of the sample before mixing with molten agar for assessment of the level of microbial contamination in carrageenan samples prior to business-to-business shipment.
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