Introduction: Low-density lipoprotein cholesterol (LDL) is an important risk factor for cardiovascular disease (CVD) and generally measured after 8-12 h fasting. However, some recent studies have pointed that non-fasting lipoproteins, especially LDL concentrations, are better indicators for demonstrating CVD risk and atherosclerosis. They asserted that nutrition is a negligible factor on changes in lipoprotein concentrations and claimed this difference as a result of hemodilution effect, caused from fluid intake and can be eliminated by applying some adjustments. We aimed to compare the fasting and non-fasting LDL values of the same individuals and discuss whether non-fasting and fasting LDL results can be used in place of each other, directly or after applying hemodilution correction models.
Material And Methods: Fasting and non-fasting blood samples of 248 apparently healthy participants were collected. Lipid panel tests, albumin and hemoglobin levels were studied in each sample. Results were evaluated in seven different models which were recommended to correct the hemodilution effect on fasting and non-fasting lipid concentrations of the same individual. Concordance of fasting and non-fasting risk group of the individual were calculated according to the National Cholesterol Education Program classification.
Results: Fasting and non-fasting LDL and non-high density lipoprotein cholesterol (non-HDL) concentrations were significantly different in every model (p < 0.001). Concordance results of fasting and non-fasting LDL and non-HDL risk groups were 63.8% and 77.9% respectively.
Conclusions: Our results demonstrated that fasting and non-fasting LDL and non-HDL concentrations could not be used in place of each other even when the results were adjusted for elimination of the hemodilution effect.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.clinbiochem.2018.08.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bitter Taste Sensitivity, Food Cravings, and Risk of Chronic Disease: A Cross-Sectional Study.
Cureus
November 2024
School of Public Health, Loma Linda University, Loma Linda, USA.
Introduction: Variation in common taste receptor type 2 member 38 (TAS2R38) haplotypes is associated with bitter taste sensitivity, but there is not much or inconsistent evidence on association with food cravings and with chronic disease risk factors. We have conducted a cross-sectional study to assess whether genetically defined taster groups would differ in their sensitivity to bitter-tasting compounds, cravings for various food groups, and risk of chronic disease risk factors. Methodology: A total of 116 non-diabetic individuals were recruited from the Loma Linda University (LLU) campus.
View Article and Find Full Text PDFDiagnostic accuracy of DIPSI criteria for diagnosing gestational diabetes mellitus in Puducherry.
J Family Med Prim Care
November 2024
Department of Community Medicine, Sri Lakshmi Narayanan Institute of Medical Science, BIHER, Puducherry, India.
Context: Gestational diabetes mellitus (GDM) is a major concern in recent years. During pregnancy, it is difficult to consume 75 g of glucose in the fasting state as pregnant women may experience symptoms such as vomiting. The Diabetes in Pregnancy Study Group India (DIPSI) criterion requires a single prick in the non-fasting state to collect the sample for diagnosing GDM.
View Article and Find Full Text PDFDiet as an Adjunct Therapy in Reducing Chemotherapy Toxicities and Improving Patients Quality of Life: A Systematic Review and Meta-Analysis.
Nutr Cancer
December 2024
School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
This review analyzed existing literature regarding the relationship between different diets and chemotherapy toxicities, as well as the quality of life (QOL) among patients undergoing treatment. It aims to identify the most advantageous diet for cancer patients. PubMed, CINAHL, and Embase were used to select randomized control trials (RCTs) assessing the relationship between a specific diet and chemotherapy toxicities and/or QOL in patients as of October 2023.
View Article and Find Full Text PDFRemnant cholesterol and long-term incidence of death in coronary artery disease patients.
Atherosclerosis
November 2024
VIVIT-Institute, Academic Teaching Hospital Feldkirch, Feldkirch, Austria; Private University in the Principality of Liechtenstein, Triesen, Liechtenstein; Drexel University College of Medicine, Philadelphia, PA, USA.
Article Synopsis
- Remnant cholesterol (RC) has gained attention as a potential lipid factor for assessing cardiovascular risk, though previous data were often imprecise due to factors like non-fasting samples.
- In a study involving 1,474 CAD patients, researchers measured RC using strictly fasting samples and tracked all-cause and cardiovascular mortality, along with major adverse cardiovascular events (MACE), over an average follow-up of 11.6 years.
- The results indicated that higher RC levels were significantly associated with increased risks of all-cause mortality, cardiovascular mortality, and MACE, regardless of patient demographics or statin use, establishing RC as a reliable indicator of residual risk in CAD patients.
Evaluation of Glycemic Control in Patients With Diabetes by a Continuous Glucose Monitoring System During the Month of Ramadan.
Cureus
October 2024
Department of Endocrinology and Metabolic Diseases, Ibn Rochd University Hospital, Casablanca, MAR.
Introduction: Ramadan presents challenges for patients with type 2 diabetes mellitus (T2DM) who choose to fast. Maintaining good glycemic control through regular monitoring during fasting is crucial. This study aims to evaluate and compare glycemic fluctuations in fasting and non-fasting T2DM patients during Ramadan.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!