AI Article Synopsis
- Cisplatin is a common anticancer drug for childhood tumors, but it can cause harmful cardiovascular effects, which can vary in severity.
- In a study with rats, researchers explored how rutin, known for its multiple health benefits, could mitigate the heart damage caused by cisplatin.
- The findings revealed that higher doses of rutin significantly reduced markers of heart stress and damage, indicating its potential to protect against cisplatin's adverse cardiovascular effects.
Article Abstract
Objective: Cisplatin is an anticancer drug used for treating childhood solid tumors. Symptoms related to cisplatin-induced cardiovascular adverse effects may be mild or severe. Rutin (vitamin P1) has many properties, including as antioxidant, anticancer, antidiabetic, antimicrobial, antiulcer, and tissue renewal properties. Therefore, we aimed to biochemically, histopathologically, and immunohistochemically demonstrate the effect of rutin on cisplatin-induced cardiotoxicity in rats.
Methods: The rats included in our study were divided into four groups: Healthy group (HE), 5-mg/kg cisplatin group (CP), 50 mg/kg rutin+5-mg/kg cisplatin (CR-50), 100-mg/kg rutin+5-mg/kg cisplatin (CR-100) group.
Results: CP group administered cisplatin had significantly increased blood, serum, and cardiac tissue malondialdehyde (MDA), interleukin 1 beta (IL-1ß), tumor necrosis factor alpha (TNF-α), troponin I, creatine kinase (CK), and CK-MB levels compared to the HE group, whereas there was a significant decrease in the total glutathione (tGSH) levels. Rutin was observed to prevent the increase in MDA, IL-1ß, TNF-α, troponin I, CK, and CK-MB levels as well as prevent the decrease in tGSH levels more significantly when administered at a 100-mg/kg dose than at a 50-mg/kg dose. Histopathologically, cardiac necrosis, dilated/congested blood vessels, hemorrhage, polymorphonuclear leukocyte, edema, and cells with pyknotic nuclei were observed in the CP group. Rutin was shown to prevent cisplatin-induced cardiac damage more effectively when used at a100-mg/kg dose than at a 50-mg/kg dose.
Conclusion: These results suggest that rutin is useful for preventing cisplatin-related cardiovascular damage.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237943 | PMC |
| http://dx.doi.org/10.14744/AnatolJCardiol.2018.32708 | DOI Listing |
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Article Synopsis
- Cisplatin, a widely used anticancer drug, is linked to heart and kidney toxicity, prompting research into protective agents like rutin, a natural compound.
- The study tested different doses of cisplatin on isolated rat hearts, measuring various cardiac functions and showing that higher doses significantly decreased heart performance metrics like left ventricular pressure.
- Administering rutin prior to and during cisplatin treatment helped protect heart function and reduced damage to cardiac muscle cells, indicating its potential as a therapeutic agent against cisplatin's toxic effects.
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