Development and cellular application of visible-light-controllable HNO releasers based on caged Piloty's acid.

Chem Commun (Camb)

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

Published: September 2018

Nitroxyl (HNO) is a gaseous molecule with unique pharmacological functions distinct from those of nitric oxide. Because HNO is highly reactive with biological molecules, spatiotemporally controllable HNO releasers are required. Herein, we report the first visible-light-controllable HNO releasers, based on caged Piloty's acid, and we demonstrate their applicability in living cells.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8cc04954hDOI Listing

Publication Analysis

Top Keywords

hno releasers
12
visible-light-controllable hno
8
releasers based
8
based caged
8
caged piloty's
8
piloty's acid
8
hno
5
development cellular
4
cellular application
4
application visible-light-controllable
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!