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Modification of gemcitabine with oxaliplatin in China for unresectable gallbladder cancer: a cost-effectiveness analysis.
Front Public Health
December 2024
Department of Pharmacy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Background: The incidence of gall bladder cancer (GBC), one of the most prevalent bile duct malignancies, differs with ethnicity and geographic location. To treat unresected GBC in the Chinese setting, this study aimed to assess the financial effectiveness of a combination of modified gemcitabine and oxaliplatin.
Methods: Data from a randomized controlled study in which individuals with metastatic GBC were treated with oxaliplatin and gemcitabine demonstrated improved survival.
Budget impact analysis of baricitinib for treatment of alopecia areata: A Saudi hospital perspective.
Saudi Pharm J
December 2024
Armed Forces Hospital Southern Region, Khamis Mushayt, Saudi Arabia.
Objectives: To perform a budget impact analysis (BIA) of the adoption of baricitinib for the management of alopecia areata (AA) by a Saudi public sector payer.
Methods: A BIA model was developed to calculate the expected financial impact under two scenarios: the baseline scenario, which reflects the current mix of treatments without baricitinib, and the projected scenario, in which baricitinib is adopted. The model assumed that patients with severe AA and those with mild-to-moderate AA who did not respond to other treatments were eligible for baricitinib treatment.
Unveiling the threat of lead, cadmium, and nickel toxicity in salient commercially grown vegetables in Kolkata, India.
Environ Monit Assess
December 2024
Amity Institute of Biotechnology, Amity University Kolkata, Major Arterial Road, AA II, Newtown, Kolkata, 700135, West Bengal, Republic of India.
Heavy metal (HM) contamination in agricultural crops, particularly vegetables, is a matter of global concern due to its potential health risks to humans. Commercially growing vegetable samples were analyzed for heavy metals using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for leafy greens and fruit vegetables collected during winter from highly susceptible zones, in the vicinity of Kolkata. ICP-MS is advantageous over Atomic Absorption Spectrometry (AAS) for unparalleled accuracy, efficiency, faster turnaround time, cost-effectiveness, etc.
View Article and Find Full Text PDF[F]fluorocholine PET . [Tc]sestamibi scintigraphy for detection and localization of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism: outcomes and resource efficiency.
Radiol Oncol
December 2024
Division of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Article Synopsis
- - Minimally invasive parathyroidectomy is the preferred treatment for primary hyperparathyroidism, but it relies on effective preoperative localization methods to identify overactive parathyroid tissue.
- - A study compared two groups of patients—234 who had traditional MIBI scintigraphy and 163 who had FCh-PET/CT—focusing on the efficiency and outcomes of these imaging techniques leading up to surgery.
- - Results showed that FCh-PET/CT significantly reduced imaging time by 83% and surgery time by 41% without using intraoperative hormone monitoring, suggesting it may lead to faster procedures and fewer reoperations for patients.
US cost-effectiveness analysis of apixaban compared with warfarin, dabigatran and rivaroxaban for nonvalvular atrial fibrillation, focusing on equal value of life years and health years in total.
J Comp Eff Res
January 2025
Health Economics & Outcomes Research Ltd., Cardiff, UK.
Warfarin and direct-acting oral anticoagulants (DOACs) are widely prescribed to patients with nonvalvular atrial fibrillation (NVAF) to reduce risk of stroke and systemic embolism (SE). This study aimed to assess the cost-effectiveness of apixaban compared with warfarin, dabigatran and rivaroxaban, for patients with NVAF from a US healthcare payer (Medicare) perspective. A cohort-level Markov model was developed based on a previously published model, for the US setting, factoring in anticipated price decreases due to market entry of generic drugs.
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