Transdisciplinary (TD) research is increasingly suggested as a means of tackling wicked problems by providing knowledge on solutions that serve as pathways towards sustainable development. In contrast to research striving for generalizable findings, TD research produces insights for a particular case and context. TD researchers, who build on other TD projects' results, need to know under what conditions knowledge gained from their case can be transferred to and applied in another case and context. Knowledge transfer between researchers and stakeholders is extensively discussed in the literature. However, a more profound understanding and management of the challenges related to knowledge transfer across cases, as it applies to TD research, are missing. We specify the challenges of knowledge transfer in TD research by distinguishing TD research for policy from conventional evidence-based policy, which relies on generalizing findings, such as randomized controlled trials. We also compare the functions that cases fulfil in other types of research that include basic, applied and ideographic research. We propose to conceptualize transferability of knowledge across cases as arguments by analogy. Methodologically, this would imply explicit consideration on whether the cases in question are sufficiently similar in relevant aspects while not dissimilar in other additional relevant aspects. On the one hand, this approach calls for explicit material considerations that are needed to learn about which aspects of cases are relevant. On the other hand, formal considerations on how to weigh perceived relevant similarities and dissimilarities of the cases at hand for transferability of knowledge, are needed. Empirical research on how projects in TD research deal with this problem is called for.
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http://dx.doi.org/10.1007/s11625-017-0444-2 | DOI Listing |
Cancer Lett
January 2025
Department of Radiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, P.R. China, 210029; The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, Jiangsu Province, China. Electronic address:
Preoperative detection of muscle-invasive bladder cancer (MIBC) remains a great challenge in practice. We aimed to develop and validate a deep Vesical Imaging Network (ViNet) model for the detection of MIBC using high-resolution Tweighted MR imaging (hrTWI) in a multicenter cohort. ViNet was designed using a modified 3D ResNet, in which, the encoder layers were pretrained using a self-supervised foundation model on over 40,000 cross-modal imaging datasets for transfer learning, and the classification modules were weakly supervised by an experiential knowledge-domain mask indicated by a nnUNet segmentation model.
View Article and Find Full Text PDFTrials
January 2025
MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, UCL, 90 High Holborn, London, WC1V 6LJ, UK.
Need For A Strategic Approach To Knowledge Transfer And Exchange: Late-phase clinical trials and systematic reviews find results that have the potential to improve health outcomes for people. However, there are often delays in these results influencing clinical practice. We developed a knowledge transfer and exchange strategy to support research teams, aiming to identify activities along the research process to maximise and accelerate the research impact.
View Article and Find Full Text PDFNat Med
January 2025
Institute of Collective Health, Federal University of Bahia (ISC/UFBA), Salvador, Brazil.
Conditional cash transfer (CCT) programs have been implemented globally to alleviate poverty. Although tuberculosis (TB) is closely linked to poverty, the effects of CCT on TB outcomes among populations facing social and economic vulnerabilities remain uncertain. Here we estimated the associations between participation in the world's largest CCT program, the Brazilian Bolsa Família Program (BFP), and the reduction of TB incidence, mortality and case-fatality rates using the nationwide 100 Million Brazilian Cohort between 2004 and 2015.
View Article and Find Full Text PDFCan J Anaesth
January 2025
Department of Medicine, Sinai Health and University of Toronto, Toronto, ON, Canada.
Purpose: The use of patient/family-centred written summaries to supplement verbal information may be useful to improve knowledge and reduce anxiety related to patient transfer from the intensive care unit (ICU) to a hospital ward. We aimed to identify essential elements to include in an ICU-specific patient-oriented discharge summary tool (PODS-ICU).
Methods: We conducted a mixed methods study.
Sci Total Environ
January 2025
Universidade Federal do Pará, Programa de Pós-Graduação em Geologia e Geoquímica, Rua Augusto Corrêa, 1, Campus Guamá, PA 66075-110 Belém, Pará, Brazil.
The knowledge of metals concentration in upwelling areas are a concern due the higher productivity of these areas In Cabo Frio Upwelling-Downwelling System (CFUS) is high primary productivity area and has been identified as an Hg hotspot to biota in SE Brazil that has been susceptible to Hg inputs, due to growing industrialization in the region. To investigate the concentration of Hg and Se metals, as well as the trophic transfer of these metals, the present study investigated Hg and Se concentrations in 64 samples collected in net mesh of >20, >64, >150 and >300 μm, in 2012, in the region's water masses. Higher mean Hg concentrations were found in zooplankton, 0.
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