Background: This study was designed to research the potential function of lncRNA in osteosarcoma (OS).
Materials And Methods: Quantitative real-time PCR, cell counting kit-8, wound healing assay, Transwell assay, flow cytometric analysis, caspase activity analysis, and Western blot were carried out.
Results: was remarkably upregulated in human OS tissues and cells, and knockdown of significantly suppressed MG63 cell proliferation, migration, and invasion and promoted apoptosis. Moreover, our mechanistic research findings verified that influenced growth and apoptosis may be partly through regulation of caspase-3 and Bcl-2. Migration and invasion were influenced via -mediated regulation of MTA1, TIMP-2, and E-cadherin.
Conclusion: Our finding demonstrates that plays vital roles in OS growth and metastasis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098425 | PMC |
| http://dx.doi.org/10.2147/OTT.S170293 | DOI Listing |
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