A constitutional jumping translocation involving the Y and acrocentric chromosomes.

Asian J Androl

Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake 470-1192, Japan Genome and Transcriptome Analysis Center, Fujita Health University, Toyoake 470-1192, Japan Center for Collaboration in Research and Education, Fujita Health University, Toyoake 470-1192, Japan Department of Obstetrics and Gynecology, Tenshi Hospital, Sapporo 065-8611, Japan Department of Pediatrics, Tenshi Hospital, Sapporo 065-8611, Japan Kamiya Ladies Clinic, Sapporo 060-0003, Japan Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo 060-8556, Japan.

Published: January 2019

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337947PMC
http://dx.doi.org/10.4103/aja.aja_60_18DOI Listing

Publication Analysis

Top Keywords

constitutional jumping
4
jumping translocation
4
translocation involving
4
involving acrocentric
4
acrocentric chromosomes
4
constitutional
1
translocation
1
involving
1
acrocentric
1
chromosomes
1

Similar Publications

Objectives: To analyze the constitution and distribution characteristics of renal pathological disease spectrum in the 2 hospitals from Guilin city and Jining city in recent 5 years.

Methods: The pathological results of inpatients with renal biopsy in the 2 hospitals from Guilin city and Jining city from April 1, 2014 to August 15, 2018 were retrospectively analyzed. A total of 1 370 renal biopsy cases were collected, including 706 cases in Affiliated Hospital of Jining Medical College (Jiyi) and 664 cases in Affiliated Hospital of Guilin Medical College (Guiyi).

View Article and Find Full Text PDF

Pleomorphic adenomas (PAs) of salivary glands are the most frequent entity of solid parotid tumors. Nonetheless, their genetics is not yet well understood. Thus, the current study characterized 14 PAs using a unique combination of cytogenetic, molecular cytogenetic and/or molecular karyotyping based approaches.

View Article and Find Full Text PDF

A constitutional jumping translocation involving the Y and acrocentric chromosomes.

Asian J Androl

January 2019

Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake 470-1192, Japan Genome and Transcriptome Analysis Center, Fujita Health University, Toyoake 470-1192, Japan Center for Collaboration in Research and Education, Fujita Health University, Toyoake 470-1192, Japan Department of Obstetrics and Gynecology, Tenshi Hospital, Sapporo 065-8611, Japan Department of Pediatrics, Tenshi Hospital, Sapporo 065-8611, Japan Kamiya Ladies Clinic, Sapporo 060-0003, Japan Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo 060-8556, Japan.

View Article and Find Full Text PDF

Multiple myeloma is a B-cell malignancy stratified in part by cytogenetic abnormalities, including the high-risk copy number aberrations (CNAs) of +1q21 and 17p(-). To investigate the relationship between 1q21 CNAs and DNA hypomethylation of the 1q12 pericentromeric heterochromatin, we treated in vitro peripheral blood cultures of 5 patients with balanced constitutional rearrangements of 1q12 and 5 controls with the hypomethylating agent 5-azacytidine. Using G-banding, fluorescence in situ hybridization, and spectral karyotyping, we identified structural aberrations and copy number gains of 1q21 in the treated cells similar to those found in patients with cytogenetically defined high-risk disease.

View Article and Find Full Text PDF

A Newborn with Genital Ambiguity, 45,X/46,XY Mosaicism, a Jumping Chromosome Y, and Congenital Adrenal Hyperplasia.

Case Rep Endocrinol

November 2013

Cytogenetics Laboratory, Department of Pathology and Laboratory Medicine, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, USA.

Disorders of sex development (DSD), formerly termed "intersex" conditions, arise from numerous causes. CAH secondary to 21-hydroxylase deficiency is the most common cause of DSD. Sex chromosome disorders, including sex chromosome mosaicism, are the second most common cause of DSD.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!