The opioid epidemic has claimed the lives of more than 183,000 individuals since 1999 and is now the leading cause of accidental death in the United States. Meanwhile, rates of incarceration have quadrupled in recent decades, and drug use is the leading cause of incarceration. Medication-assisted treatment or MAT (i.e. methadone, buprenorphine) is the gold standard for treatment of opioid use disorder. Incarcerated individuals with opioid use disorder treated with methadone or buprenorphine have a lower risk of overdose, lower rates of hepatitis C transmission, and lower rates of re-incarceration. Despite evidence of improved outcomes, many jails and prisons do not offer MAT to individuals with opioid use disorder. This seems partly due to a scientifically unjustified preference for an abstinence-only treatment approach. The absence of MAT in prisons and jails results in poor outcomes for individuals and poses a public health threat to communities. Furthermore, it disproportionately harms poor communities and communities of color. Health care providers in prisons and jails have an ethical obligation to offer MAT to individuals with opioid use disorder to mitigate risk of infectious diseases, opioid overdose and health disparities associated with incarceration.
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http://dx.doi.org/10.1177/1073110518782933 | DOI Listing |
J Obstet Gynaecol Can
January 2025
Department of Family and Community Medicine, Western Michigan University.
Xylazine, an alpha-adrenergic agent, is a common adulterant in the non-prescribed opioid supply. It has multiplicative sedative effects when used with opioids and these effects can negatively impact pregnancy. Given that the opioid epidemic in Canada is not abating and continues to evolve, cases of xylazine exposure during pregnancy are beginning to present in obstetrical units and emergency departments.
View Article and Find Full Text PDFPublic Health
January 2025
American Institute for Economic Research, United States. Electronic address:
Objectives: To develop a more robust understanding of the relationship between increased recreational marijuana access and opioid overdose deaths. Increasing opioid-related deaths in conjunction with the rising popularity of liberalized marijuana laws make additional research examining the interrelation of both a timely and insightful question.
Study Design: We use synthetic control method to assess the impact of opening recreational marijuana dispensaries via recreational marijuana legalization (RML) on opioid death rates in Colorado, Washington, and Oregon.
J Neuroimmunol
January 2025
Immunology Laboratory, Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar 140001, Punjab, India. Electronic address:
Morphine is a globally prevalent substance of misuse, renowned for its immunosuppressive effects mediated through opioid receptors expressed on immune cells. Macrophages are crucial antigen-presenting cells that fulfill diverse roles, such as antigen presentation, phagocytosis, wound healing, and disease protection. They are typically classified based on their activation states: M1 (proinflammatory), M2 (anti-inflammatory), and M0 (resting).
View Article and Find Full Text PDFAm J Drug Alcohol Abuse
January 2025
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kratom is a plant with alkaloids acting at opioid, serotonergic, adrenergic, and other receptors. Consumers report numerous use motivations. To distinguish subgroups of kratom consumers by kratom-use motivations using latent-class analysis.
View Article and Find Full Text PDFJMIR Form Res
January 2025
Faculty of Medicine, The University of Queensland, Brisbane, Australia.
Background: Opioid medications are important for pain management, but many patients progress to unsafe medication use. With few personalized and accessible behavioral treatment options to reduce potential opioid-related harm, new and innovative patient-centered approaches are urgently needed to fill this gap.
Objective: This study involved the first phase of co-designing a digital brief intervention to reduce the risk of opioid-related harm by investigating the lived experience of chronic noncancer pain (CNCP) in treatment-seeking patients, with a particular focus on opioid therapy experiences.
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