AI Article Synopsis
- Breast cancer develops through a multi-step process where genetic and molecular changes occur at various stages, starting from pre-invasive conditions like atypical ductal hyperplasia (ADH) to invasive cancer.
- * Obtaining tissue samples from all these stages in the same patient is challenging, complicating studies on how pre-invasive lesions transition to invasive cancers.
- * The review highlights various mouse models that simulate early-stage breast cancer, evaluating how well these models replicate human disease characteristics.
Article Abstract
Breast cancer development is a multi-step process in which genetic and molecular heterogeneity occurs at multiple stages. Ductal carcinoma arises from pre-invasive lesions such as atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS), which progress to invasive and metastatic cancer. The feasibility of obtaining tissue samples from all stages of progression from the same patient is low, and thus molecular studies dissecting the mechanisms that mediate the transition from pre-invasive DCIS to invasive carcinoma have been hampered. In the past 25 years, numerous mouse models have been developed that partly recapitulate the histological and biological properties of early stage lesions. In this review, we discuss in vivo model systems of breast cancer progression from syngeneic mouse models to human xenografts, with particular focus on how accurately these models mimic human disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244883 | PMC |
| http://dx.doi.org/10.1007/s10911-018-9408-0 | DOI Listing |
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