AI Article Synopsis

  • Serum electrolyte imbalances are common in patients with decompensated cirrhosis experiencing hepatic encephalopathy, but their impact on patient outcomes is poorly understood.
  • A study involving 385 patients measured baseline electrolyte levels at admission and assessed their correlation with outcomes like survival and ICU admission.
  • While initial analysis showed some associations with bicarbonate and phosphorus levels, these lost significance after accounting for other factors, indicating that electrolyte levels are not reliable predictors of outcomes in hepatic encephalopathy.

Article Abstract

Introduction And Aims: Serum electrolyte derangements are common in patients with decompensated cirrhosis hospitalized for hepatic encephalopathy. There are limited data describing the association between electrolyte levels and outcomes in hepatic encephalopathy. We assessed the association between initial serum electrolyte values and outcomes in patients with hepatic encephalopathy.

Material And Methods: A total of 385 consecutive patients hospitalized with encephalopathy were included in the study. Baseline electrolyte levels (sodium, potassium, chloride, bicarbonate, calcium and phosphorus) were measured at the time of admission and assessed for association with outcomes, which included survival, admission to the intensive care unit, requirement for mechanical ventilation, and length of hospital stay. P-values ≤ 0.0083 were considered significant after adjustment for multiple testing.

Results: In unadjusted analysis, significant associations were identified regarding both bicarbonate and phosphorus (admission to intensive care unit), and calcium (mechanical ventilation); however these findings weakened and no longer approached statistical significance when adjusting for confounding variables. No other significant associations between serum electrolyte measurements and outcomes were observed.

Conclusions: Our findings suggest that in patients hospitalized with encephalopathy, serum electrolyte measurements are not strong predictors of patient outcome.

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http://dx.doi.org/10.5604/01.3001.0012.3144DOI Listing

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