A vacuum membrane distillation bioreactor (VMDBR) by permeate fractional condensation and mechanical vapor compression with PTFE membrane was developed for bioethanol production. Cell concentration of 11.5 g/L, glucose consumption rate of 5.2 g/L/h and ethanol productivity of 2.3 g/L/h could be obtained with fermentation continues lasting for 140 h. Membrane flux of over 10 kg/m/h could be obtained for model solution separation. Higher temperature and flow rate could promote membrane separation. Membrane flux could be reduced to about 2000 g/m/h with fermentation proceeding owing to the deposited cell on membrane surface. The membrane separation performance could be resumed by water rinse. High ethanol concentration of 421 g/L could be obtained by permeate fractional condensation with the process separation factor increased to 19.2. Energy of only 14 MJ/kg was required in VMDBR and the energy consumption would be reduced further if the compressed vapor could be used to heat the feed.
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