Background: Increased PM concentrations are commonly observed during Saharan dust advections. Limited epidemiological evidence suggests that PM from anthropogenic and desert sources increase mortality. We aimed to evaluate the association between source-specific PM (non-desert and desert) and cause-specific mortality in Sicily during 2006-2012 period.
Methods: Daily PM concentrations at 1-km were estimated in Sicily using satellite-based data, fixed monitors and land use variables. We identified Saharan dust episodes using meteorological models, back-trajectories, aerosol maps, and satellite images. For each dust day, we estimated desert and non-desert PM concentrations. We applied a time-series approach on 390 municipalities of Sicily to estimate the association between PM (non-desert and desert) and daily cause-specific mortality.
Results: 33% of all days were affected by Saharan dust advections. PM concentrations were 8 μg/m higher during dust days compared to other days. We found positive associations of both non-desert and desert PM with cause-specific mortality. We estimated percent increases of risk (IR%) of non-accidental mortality equal to 2.3% (95% Confidence Interval [CI]: 1.4, 3.1) and 3.8% (3.2, 4.4), per 10 μg/m increases in non-desert and desert PM at lag 0-5, respectively. We also observed significant associations with cardiovascular (2.4% [1.3, 3.4] and 4.5% [3.8, 5.3]) and respiratory mortality (8.1% [6.8, 9.5], and 6.3% [5.4, 7.2]). We estimated higher effects during April-September, with IR% = 4.4% (3.2, 5.7) and 6.3% (5.4, 7.2) for non-desert and desert PM, respectively.
Conclusions: Our results confirm previous evidence of harmful effects of desert PM on non-accidental and cardio-respiratory mortality, especially during the warm season.
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http://dx.doi.org/10.1016/j.envint.2018.08.016 | DOI Listing |
Physiol Plant
October 2024
Botany, School of Natural Sciences, Trinity College Dublin, Dublin 2, Ireland.
Nat Commun
October 2024
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, 100142, Beijing, China.
To tackle the clinical challenge of noninvasively assessing immunotherapy efficacy in patients, here we used positron emission tomography (PET) with Ga-grazytracer, which targets granzyme B, a crucial effector molecule secreted by activated CD8 T cells. In this phase 1/2 clinical trial (NCT05000372) involving a diverse cohort of 24 patients with solid tumors and lymphomas who received immunotherapies, including immune checkpoint inhibitors (either alone or with chemotherapies) and chimeric antigen receptor-T cell therapy, we examined the in vivo behaviors of Ga-grazytracer. Primary endpoints were safety, biodistribution, granzyme B specificity, and the predictive utility of Ga-grazytracer, while secondary endpoint was the relationship between Ga-grazytracer uptake and tumor immune phenotype.
View Article and Find Full Text PDFBMC Biol
August 2023
Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing, 100101, China.
Background: Environmental conditions vary among deserts across the world, spanning from hyper-arid to high-elevation deserts. However, prior genomic studies on desert adaptation have focused on desert and non-desert comparisons overlooking the complexity of conditions within deserts. Focusing on the adaptation mechanisms to diverse desert environments will advance our understanding of how species adapt to extreme desert environments.
View Article and Find Full Text PDFGenome Biol Evol
November 2022
Department of Integrative Biology and Museum of Vertebrate Zoology, 3101 Valley Life Sciences Building, University of California Berkeley, California 94720.
Desert specialization has arisen multiple times across rodents and is often associated with a suite of convergent phenotypes, including modification of the kidneys to mitigate water loss. However, the extent to which phenotypic convergence in desert rodents is mirrored at the molecular level is unknown. Here, we sequenced kidney mRNA and assembled transcriptomes for three pairs of rodent species to search for shared differences in gene expression and amino acid sequence associated with adaptation to deserts.
View Article and Find Full Text PDFNutr Health
December 2021
Department of Nutritional Sciences, 6186University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Background: Higher produce consumption in childhood decreases risks of short- and long-term malnutrition, obesity, and disease. Children in early care programs, including family child care homes (FCCHs), receive 50-67% of daily nutrition while in care. Procuring nutritious foods requires grocer access, which is absent in food deserts (FDs).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!