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Background: Recurrent miscarriage is considered as one of the main problems in women's reproductive health. The aim of the present study was to evaluate the natural killer cells (NK cells) and cytokines in unexplained recurrent miscarriage and fertile women.
Methods: In this case-control study, 40 women with unexplained recurrent miscarriage were assigned to the case group and 40 fertile women were assigned to the control group. NK cell subsets (CD56 CD16/CD56 CD16) and cytokines (IL-2/IL-12) levels in the peripheral blood (PB) were used for assessing immunologic problems. The percentage of peripheral blood NK cells (CD56) was identified by flow cytometry.
Results: The obtained results showed a significant difference in CD56 CD16 and CD56 CD16 between the two groups. Also, there was no significant difference in the IL-2 and IL-12 between the two groups. A cut-off value of ≥5.25% (p < 0.001) and ≥3.4% (p < 0.015) for the increased percentage of CD56 CD16 and CD56 CD16cells in the PB become predictive of recurrent miscarriage.
Conclusion: Increased NK cells in the PB of women with recurrent miscarriage strongly establish prospective researches to recognize the predictive value of these parameters in the evaluation of patients with recurrent miscarriage.
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| http://dx.doi.org/10.1016/j.jcma.2018.05.005 | DOI Listing |
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