AI Article Synopsis
- Major antimicrobial resistance poses a significant threat to public health, potentially reversing progress made in treating infections.
- A study conducted in a hospital in Bhubaneswar found high levels of extensively drug-resistant (XDR) and pandrug-resistant (PDR) Gram-negative bacteria, with 41.3% classified as XDR and 8.1% as PDR.
- The results highlight the urgent need for ongoing monitoring of antimicrobial resistance and effective infection control measures in healthcare settings.
Article Abstract
Objectives: Bacteria resistant to different classes of antimicrobial agents are a major threat to humanity and risk leading the world towards the return of the pre-antimicrobial era. This study was undertaken to detect the incidence of extensively drug-resistant (XDR) and pandrug-resistant (PDR) bacteria in a tertiary-care hospital in Bhubaneswar, Odisha, India.
Methods: Positive bacterial cultures from different clinical samples were identified using a VITEK2 compact system and the antimicrobial susceptibility profile of different Gram-negative bacteria was analysed.
Results: A total of 2489 clinical samples were collected and processed for culture during the period January 2013 to April 2017. Of 1103 pure bacterial cultures, 690 (62.6%) were Gram-negative bacteria. The antimicrobial susceptibility profile of Gram-negative bacterial strains revealed that 41.3% (n=285) were XDR and 8.1% (n=56) were PDR. Rates of colistin and tigecycline resistance were 16% and 51.9%, respectively.
Conclusion: This situation demands regular surveillance of antimicrobial resistance of Gram-negative bacteria and implementation of an efficient infection control programme.
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| http://dx.doi.org/10.1016/j.jgar.2018.08.010 | DOI Listing |
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