Crystalline retinopathies may be associated with different etiologies including genetic, toxic, degenerative, idiopathic, and iatrogenic causes. We outline the various types of crystalline retinopathies and summarize their associated etiologies, pathogenesis, clinical presentations, multimodal imaging findings, and management strategies.
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Safety and Vision Outcomes Following Gene Therapy for Bietti Crystalline Dystrophy: A Nonrandomized Clinical Trial.
JAMA Ophthalmol
January 2025
Xiamen Eye Center of Xiamen University, Xiamen, Fujian, China.
Importance: Bietti crystalline dystrophy (BCD) is a severe genetic retinopathy caused by variants in the CYP4V2 gene. Currently, there is no approved treatment for BCD.
Objective: To evaluate safety and vision outcomes following gene therapy with adeno-associated virus (AAV) encoding CYP4V2 (rAAV-hCYP4V2, NGGT001 [Next Generation Gene Therapeutics]).
Long-term sequelae of stage 4A ROP after successful management with lens-sparing vitrectomy.
BMJ Case Rep
December 2024
Department of Ophthalmology, Government Medical College and Hospital, Chandigarh, Chandigarh, India.
We present an unusual case of a macular lesion, possibly a spontaneously closed macular hole, at a 4-year follow-up visit, after lens-sparing vitrectomy (LSV) in stage 4A retinopathy of prematurity (ROP). Optical coherence tomography scans of the macula were suggestive of a spontaneously closed macular hole and fibrovascular proliferation at the equator. We hypothesise that tangential traction by residual posterior hyaloid could lead to late macular hole formation after LSV in ROP.
View Article and Find Full Text PDFNovel mTORC2/HSPB4 Interaction: Role and Regulation of HSPB4 T148 Phosphorylation.
Cells
December 2024
Department of Ophthalmology & Visual Sciences, The University of Michigan, Ann Arbor, MI 48109, USA.
HSPB4 and HSPB5 (α-crystallins) have shown increasing promise as neuroprotective agents, demonstrating several anti-apoptotic and protective roles in disorders such as multiple sclerosis and diabetic retinopathy. HSPs are highly regulated by post-translational modification, including deamidation, glycosylation, and phosphorylation. Among them, T148 phosphorylation has been shown to regulate the structural and functional characteristics of HSPB4 and underlie, in part, its neuroprotective capacity.
View Article and Find Full Text PDFUntargeted Metabolomics Reveals the Role of Lipocalin-2 in the Pathological Changes of Lens and Retina in Diabetic Mice.
Invest Ophthalmol Vis Sci
December 2024
Eye Center of Xiangya Hospital, Central South University, Changsha, China.
Purpose: To identify the role of lipocalin-2 (LCN2) in diabetic cataract (DC) and diabetic retinopathy (DR), diabetes models were established in wild-type (WT) and LCN2 gene knockout (LCN2-/-) mice by streptozotocin (STZ), this study aimed to investigate the metabolic alterations and underlying pathways in the lens and retina.
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Unveiling the Mysteries of the Chinese lens zonule balance tension: A statistical analysis.
Heliyon
October 2024
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, China.
Background: This study aims to provide an estimated dataset of lens zonule balance tension (LZBT) measurements in cataractous lenses among Chinese patients and to conduct a statistical analysis of anterior segment parameters.
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