Recently, we have identified an extensively drug-resistant (XDR) Streptococcus pneumoniae serotype 15A isolate from a patient with bacterial meningitis. It belonged to sequence type 8279 (ST8279), a clone identified as XDR serotype 11A isolated in South Korea. We obtained and compared the genome sequences of an XDR 15A and an XDR 11A isolate. The genomes of two XDR isolates were highly identical, except for the capsular polysaccharide (cps) locus and another small region. Capsular switching from 11A to 15A may have occurred via recombination of the cps locus. The emergence of a new XDR clone via capsular switching would be a great concern for public health and in clinical settings.
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http://dx.doi.org/10.1016/j.ijmm.2018.08.004 | DOI Listing |
Genome Med
October 2024
Department of Biostatistics, Faculty of Medicine, University of Oslo, Oslo, Norway.
Fluoroquinolone-resistant sequence type (ST)1193 is a profound, emerging lineage associated with systemic, urinary tract and neonatal infections. Humans, companion animals and the environment are reservoirs for ST1193, which has been disseminated globally. Following its detection in 2007, ST1193 has been identified repeatedly amongst fluoroquinolone-resistant clones in Australia.
View Article and Find Full Text PDFVet Res
September 2024
Groupe de recherche sur les maladies infectieuses en production animale, and Centre de recherche en infectiologie porcine et avicole, Faculté de médecine vétérinaire, Université de Montréal, St-Hyacinthe, QC, Canada.
Streptococcus suis is a major swine pathogen and zoonotic agent, causing important economic losses to the porcine industry. Here, we used genomics approaches to characterize 251 S. suis isolates recovered from diseased pigs across Belgium, France, Germany, Hungary, the Netherlands, Spain, and the United Kingdom.
View Article and Find Full Text PDFTetrahedron
September 2024
Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
We developed a method for making immune responses to bacterial glycans T cell-dependent, which involves attachment of short, synthetic glycans to a virus-like nanoparticle (VLP). This strategy enhances immune responses to glycans by facilitating cognate T cell help of B cells, leading to antibody class switching and affinity maturation yielding high-affinity, anti-glycan antibodies. This method requires synthesis of bacterial glycans as propargyl glycosides for covalent attachment to VLPs, and the resulting short linker between the VLP and glycan is important for optimal T cell receptor recognition.
View Article and Find Full Text PDFSci Rep
September 2024
Division for Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
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