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Cost-benefit analysis of serological and nucleic acid testing for hepatitis B virus in blood donors in southern China.
BMC Infect Dis
September 2024
The Joint-laboratory of Transfusion-transmitted Diseases (TTDs) between Institute of Blood Transfusion (IBT), Chinese Academy of Medical Sciences (CAMS) and Nanning Blood Center, Nanning Blood Center, Nanning, Guangxi, 530003, China.
Background: Most Chinese blood centers have implemented mini pool (MP) HBV nucleic acid testing (NAT) together with HBsAg ELISA in routine blood donor screening for HBV infection since 2015, and a few centers upgraded MP to individual donation (ID) NAT screening recently, raising urgent need for cost-benefit analysis of different screening strategies. In an effort to prevent transfusion-transmitted infections (TTIs) for HBV, cost-benefit analyses of three different screening strategies: HBsAg alone, HBsAg plus MP NAT and HBsAg plus ID NAT were performed in blood donors from southern China where HBV infection was endemic.
Methods: MP-6 HBV NAT and ID NAT were adopted in parallel to screen blood donors for further comparative analysis.
Parvovirus B19 DNA and antibodies in Chinese plasma donors, plasma pools and plasma derivatives.
PeerJ
August 2023
Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China.
Background: Human parvovirus B19 (B19V) is a common contaminant found in plasma pools and plasma derivatives. Previous studies were mainly focused on limited aspects, further assessment of prevalence of B19V DNA and antibodies in plasma donors, the contamination of B19V in pooled plasma and plasma derivatives should be performed in China.
Study Design And Methods: Individual plasma donors' samples from four provinces and pooled plasma from four Chinese blood product manufacturers were collected and screened using B19V DNA diagnostic kits between October 2018 and May 2020.
Intravenous Immunoglobulin G (IVIG) Need Assessment Survey Toward Local Manufacturing of IVIG Using a Mini-Pool Plasma Fractionation Technique.
Health Serv Insights
February 2023
Armauer Hansen Research Institute, Biotechnology and Bioinformatics Directorate, Addis Ababa, Ethiopia.
Immunoglobulin therapy has a crucial role in the treatment of primary and secondary immunodeficiencies as well as in a multitude of neurologic, hematologic, infectious, and autoimmune conditions. In the current study, a preliminary pilot scale needs assessment survey was conducted to examine the need for IVIG among patients in Addis Ababa, Ethiopia, and in so doing justify local manufacturing of IVIG products. The survey was performed by administering a structured questionnaire to private and government hospitals, a national blood bank, a regulatory body, and healthcare researchers working in academia and pharmaceutical companies.
View Article and Find Full Text PDFEffectiveness Of Pcr Pool Testing For Screening Of Covid-19 Infection In Pakistan.
J Ayub Med Coll Abbottabad
December 2022
Institute of Pathology and Diagnostic Medicine, Khyber Medical University, Peshawar and Rehman Medical Institute, Peshawar, Pakistan.
Background: We tested the utility of mini-pool PCR testing for the rational use of PCR consumables in screening for CoViD-19.
Methods: After pilot experiments, 3-samples pool size was selected. One step RT-PCR was performed.
Risk of a blood donation contaminated with hepatitis E virus entering the blood supply before the implementation of universal RNA screening in France.
Vox Sang
December 2022
Etablissement Français du Sang, La Plaine St-Denis, France.
Background And Objectives: The risk of a blood donation contaminated with hepatitis E virus (HEV) entering the blood supply before introducing universal HEV-RNA screening in France was estimated to assess the benefit of such a measure.
Materials And Methods: The results of selective HEV nucleic acid testing (HEV-NAT) performed in mini pool of six plasma donations between 2018 and 2020 were extrapolated to the whole blood donor (BD) population after adjustment on three variables: regional establishment, sex and age group.
Results: Among the 246,285 plasma donations collected from 172,635 BDs tested for HEV-RNA, 248 (10.
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