Neonate-omics: Charting the Unknown Immune Response in Early Life.

Cell

The Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address:

Published: August 2018

AI Article Synopsis

  • - Neonatal immunology research has faced challenges due to limited access to infant samples, but new techniques are helping to overcome this issue.
  • - Recent studies show that newborn immunity differs significantly but starts to become more uniform within the first three months after birth.
  • - During these crucial first months, both environmental and genetic factors play a significant role in shaping the infant's immune system, potentially affecting immunity throughout their life.

Article Abstract

The study of neonatal immunology has been hampered by lack of access to infant samples. Novel sample sparing methods and systems-wide approaches have uniquely expanded this field, demonstrating that newborn immunity varies widely but converges over the first 3 months of life. During this important time window, environmental and genetic factors impact the infant immune system and can influence lifelong immunity.

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Source
http://dx.doi.org/10.1016/j.cell.2018.08.001DOI Listing

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Article Synopsis
  • - Neonatal immunology research has faced challenges due to limited access to infant samples, but new techniques are helping to overcome this issue.
  • - Recent studies show that newborn immunity differs significantly but starts to become more uniform within the first three months after birth.
  • - During these crucial first months, both environmental and genetic factors play a significant role in shaping the infant's immune system, potentially affecting immunity throughout their life.
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