We report a rare case of a 71-year-old female who presented to the First Clinic of Surgery from “Sf. Spiridon” Hospital Iasi, Romania with a mass in the left iliac fossa that started to discharge a feculent secretion five days prior to presentation. The patient had a history of constipation, several episodes of hematochezia associated with significant weight loss over the past 6 months. Following evaluation, a diagnosis of enter cutaneous fistula secondary to a locally advanced sigmoid cancer was made. The patient underwent semi-elective resection of the sigmoid tumor (measuring 20 cm) with 10 cm safe margins, and of the involved lymph nodes and abdominal wall. A termino-terminal colo-rectal anastomosis was performed. The patient was discharged the 10th postoperative day after an uneventful evolution for oncological evaluation. The authors presented this case in order to illustrate the challenges associated with diagnostic and therapeutic management of advanced colorectal cancer that has been discovered through a parietal abscess.
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Menopause
January 2025
From the Department of Radiology, Mayo Clinic, Rochester, MN.
Objective: To assess the association of systolic and diastolic blood pressure (SBP and DBP) in recently menopausal women with white matter hyperintensity (WMH) volume later in life and determine whether short-term menopausal hormone therapy (mHT) modifies these associations.
Methods: Kronos Early Estrogen Prevention Study (KEEPS) was a multicenter, randomized, double-blinded, placebo-controlled 4-year mHT trial (oral conjugated equine estrogens or transdermal 17β-estradiol). KEEPS continuation was an observational follow-up of the participants 10 years after the end of mHT.
Clin Park Relat Disord
November 2024
Department of Neurology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Introduction: Creutzfeldt-Jakob disease (CJD) is a rare, rapidly progressive, fatal, neurodegenerative disease classified as prion diseases. There are many subtypes of this disease, but information about clinical presentation and investigation findings in Thailand is scarce.
Objective: To describe the clinical presentation, radiological and electroencephalographic characteristics of CJD encountered at Siriraj hospital in the past 10 years (between January 1, 2006 and December 31, 2015).
Neuroimage
December 2024
Department of General Psychology, University of Padova, via Venezia 8, 35131 Padova, Italy; Padova Neuroscience Center, University of Padova, via Orus 2/B, 35129 Padova, Italy. Electronic address:
The impacting research on emotions of the last decades was carried out with different methods. The most popular was based on the use of a validated sample of slides, the International Affective Pictures System (IAPS), divided mainly into pleasant, neutral and unpleasant categories, and on fMRI as a measure of brain activation induced by these stimuli. With the present coordinate-based meta-analysis (CBMA) based on ALE approach, we aimed to unmask the main brain networks involved in the contrast of pleasant vs.
View Article and Find Full Text PDFHum Brain Mapp
December 2024
Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
The traditional analytical framework taken by neuroimaging studies in general, and lesion-behavior studies in particular, has been inferential in nature and has focused on identifying and interpreting statistically significant effects within the sample under study. While this framework is well-suited for hypothesis testing approaches, achieving the modern goal of precision medicine requires a different framework that is predictive in nature and that focuses on maximizing the predictive power of models and evaluating their ability to generalize beyond the data that were used to train them. However, few tools exist to support the development and evaluation of predictive models in the context of neuroimaging or lesion-behavior research, creating an obstacle to the widespread adoption of predictive modeling approaches in the field.
View Article and Find Full Text PDFEur J Neurosci
January 2025
Department of Psychology, Institute of Education, China West Normal University, Nanchong, China.
Information conveyed through feedback enables individuals to learn new routines and better adapt to their environment. However, the neural mechanisms of rule-related information of feedback have not been fully elucidated. Herein, we quantified the effect of informative value on feedback via a rule induction task (RIT), in which participants were required to find the correct sorting rule based on feedback.
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