AI Article Synopsis
- Omalizumab is a monoclonal antibody that helps treat moderate-to-severe allergic asthma by inhibiting free immunoglobulin E, showing effectiveness mainly in adolescents and adults, but also in children aged 6-12.
- The article reviews various studies focused on the efficacy and safety of omalizumab in young children, discusses its integration into pediatric asthma management guidelines, and examines its pharmacoeconomic aspects.
- Expert commentary suggests that omalizumab is a safe and effective add-on therapy for children aged 6-12 with poorly controlled asthma, especially when used with other medications like corticosteroids and β2-agonists.
Article Abstract
Omalizumab is a monoclonal antibody that binds and inhibits free serum immunoglobulin E, a mediator involved in the clinical manifestations of allergic asthma. Evidence for its efficacy and safety in the treatment of moderate-to-severe allergic asthma is based primarily on studies in adolescents and adults. However, there is increasing evidence of its utility in children with allergic asthma aged 6-12 years. Areas covered: This article reviews efficacy, safety, and effectiveness of omalizumab in the treatment of moderate-to-severe allergic asthma in children aged 6-12 years in clinical trials and in studies in clinical practice. Pharmacoeconomic aspects of its use among this population and the positioning of omalizumab in pediatric asthma management guidelines are also discussed. Additionally, an algorithm for the management of poorly controlled severe pediatric asthma in children older than 6 years is proposed. Electronic databases, such as PubMed, were searched for terms Asthma and Omalizumab and for asthma management guidelines. Expert commentary: Add-on omalizumab is an effective maintenance therapy in children aged 6-12 years with poorly controlled moderate-to-severe allergic asthma treated with medium-high inhaled corticosteroids doses and inhaled long-acting β2-agonists. Omalizumab appears safe in children in both clinical trials and real-life setting and may be cost-effective.
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| http://dx.doi.org/10.1080/17476348.2018.1507740 | DOI Listing |
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