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Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. | LitMetric

AI Article Synopsis

  • Positron emission tomography (PET) is currently the main metabolic imaging technique used in clinics, but it has limitations, especially in interpreting results for high glucose-using organs like the brain.
  • Deuterium metabolic imaging (DMI) is a new, noninvasive technique that creates detailed 3D maps of metabolism by using labeled substrates, allowing for insights into glucose metabolism beyond just uptake.
  • DMI has shown promise in identifying metabolic differences in brain tumors and tracking glucose storage in the liver, indicating its potential for broader application in (pre)clinical research and clinical settings.

Article Abstract

Currently, the only widely available metabolic imaging technique in the clinic is positron emission tomography (PET) detection of the radioactive glucose analog 2-F-fluoro-2-deoxy-d-glucose (FDG). However, FDG-PET does not inform on metabolism downstream of glucose uptake and often provides ambiguous results in organs with intrinsic high glucose uptake, such as the brain. Deuterium metabolic imaging (DMI) is a novel, noninvasive approach that combines deuterium magnetic resonance spectroscopic imaging with oral intake or intravenous infusion of nonradioactive H-labeled substrates to generate three-dimensional metabolic maps. DMI can reveal glucose metabolism beyond mere uptake and can be used with other H-labeled substrates as well. We demonstrate DMI by mapping metabolism in the brain and liver of animal models and human subjects using [6,6'-H]glucose or [H]acetate. In a rat glioma model, DMI revealed pronounced metabolic differences between normal brain and tumor tissue, with high-contrast metabolic maps depicting the Warburg effect. We observed similar metabolic patterns and image contrast in two patients with a high-grade brain tumor after oral intake of H-labeled glucose. Further, DMI used in rat and human livers showed [6,6'-H]glucose stored as labeled glycogen. DMI is a versatile, robust, and easy-to-implement technique that requires minimal modifications to existing clinical magnetic resonance imaging scanners. DMI has great potential to become a widespread method for metabolic imaging in both (pre)clinical research and the clinic.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105304PMC
http://dx.doi.org/10.1126/sciadv.aat7314DOI Listing

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