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Targeted inhibition of PqsR in Pseudomonas aeruginosa PAO1 quorum-sensing network by chalcones as promising antibacterial compounds.
Mol Biol Rep
January 2025
Department of Pharmaceutical Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Background: Pseudomonas aeruginosa's inherent and adapted resistance makes this pathogen a serious problem for antimicrobial treatments. Furthermore, its biofilm formation ability is the most critical armor against antimicrobial therapy, and the virulence factors, on the other hand, contribute to fatal infection and other recalcitrant phenotypic characteristics. These capabilities are harmonized through cell-cell communication called Quorum Sensing (QS), which results in gene expression regulation via three major interconnected circuits: las, rhl, and pqs system.
View Article and Find Full Text PDFCrude Antibiotics and Antifungal Metabolites from Chaetomium globosum Cg6 Suppress Pythium aphanidermatum, Causal Agent of Rhizome Rot of Turmeric.
Curr Microbiol
January 2025
Department of Plant Pathology, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, 641003, India.
Turmeric is affected by various phytopathogens, which cause huge economic losses to farmers. In the present study, ten isolates of Pythium spp. were isolated from infected turmeric rhizomes and characterized.
View Article and Find Full Text PDFControl of virulence and physiology by the flagellin homeostasis checkpoint FliC-FliW-CsrA in the absence of motility.
mBio
January 2025
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Unlabelled: Mutations affecting flagellin (FliC) have been shown to be hypervirulent in animal models and display increased toxin production and alterations in central metabolism. The regulation of flagellin levels in bacteria is governed by a tripartite regulatory network involving , , and , which creates a feedback system to regulate flagella production. Through genomic analysis of clade 5 strains (non-motile), we identified they have jettisoned many of the genes required for flagellum biosynthesis yet retain the major flagellin gene and regulatory gene .
View Article and Find Full Text PDFRecurrence of skin and soft tissue infections: identifying risk factors and treatment strategies.
Curr Opin Infect Dis
January 2025
Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna.
Purpose Of Review: Recurrent skin and soft tissue infections (RSSTIs) are challenging for the clinicians due to morbidity and healthcare-related costs. Here, we review updates on risk factors and management.
Recent Findings: RSSTIs rates range between 7 and 45%.
The challenge of antimicrobial resistance in the Asia-Pacific: a pediatric perspective.
Curr Opin Pediatr
January 2025
Sydney Children's Hospital, Randwick, NSW.
Purpose Of Review: The densely populated Asia Pacific region is home to 600 million children, and suffers from a significant burden of morbidity and mortality due to infections associated with antimicrobial resistance (AMR). We aimed to identify the drivers, challenges and potential opportunities to alter the burden of AMR within the region.
Recent Findings: Despite the high AMR burden borne by the Asia Pacific region, there are limited (and geographically imbalanced) published data to delineate the contemporary epidemiology of serious multidrug-resistant bacterial infections in children.
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