AI Article Synopsis
- Danish customs seized unknown pharmaceutical preparations and analyzed them using liquid chromatography-high resolution mass spectrometry (LC-HRMS).
- The analysis revealed that the powders contained analogs of various growth hormone secretagogues like GHRP-2, GHRP-6, and Ipamorelin, which are known performance enhancers.
- All identified substances had a modification involving an additional glycine amino acid at the start, highlighting the need to update analytical methods for detecting growth hormone secretagogues.
Article Abstract
A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography-high resolution mass spectrometry (LC-HRMS) analysis. Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP-2 (Pralmorelin), GHRP-6, Ipamorelin, and modified growth hormone releasing factor (modified GRF 1-29), which can be used as performance-enhancing substances in sports. In all cases, the detected modification involved the addition of an extra glycine amino acid at the N-terminus, and analytical methods targeting growth hormone secretagogues should hence be updated accordingly.
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| http://dx.doi.org/10.1002/dta.2489 | DOI Listing |
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