Objective: To examine whether interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity (PACAP38-LI) shows correlation with the microstructural integrity of the white matter in migraine.
Methods: Interictal plasma PACAP38-LI was measured by radioimmunoassay in 26 patients with migraine (24 women) who underwent diffusion tensor imaging afterward using a 1.5-tesla magnetic resonance scanner. Data were analyzed using tract-based spatial statistics included in FMRIB's Software Library.
Results: Interictal plasma PACAP38-LI showed significant correlation with mean diffusivity ( < 0.0179) mostly in the bilateral occipital white matter spreading into parietal and temporal white matter. Axial and radial diffusivity showed positive correlation with interictal PACAP38-LI ( < 0.0432 and < 0.0418, respectively) in the left optic radiation and left posterior corpus callosum. Fractional anisotropy did not correlate significantly with PACAP38-LI. With disease duration as a nuisance regressor in the model, PACAP38-LI correlated with axial and mean diffusivity in the left thalamus ( < 0.01).
Conclusion: We report a link between PACAP38, a pathobiologically important neurochemical biomarker, and imaging markers of the disease that may bolster further research into the role of PACAP38 in migraine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1212/WNL.0000000000006201 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Doxycycline for the treatment of nodding syndrome: a randomised, placebo-controlled, phase 2 trial.
Lancet Glob Health
July 2024
Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
Background: Nodding syndrome is a poorly understood neurological disorder that predominantly occurs in Africa. We hypothesised that nodding syndrome is a neuroinflammatory disorder, induced by antibodies to Onchocerca volvulus or its Wolbachia symbiont, cross-reacting with host neuronal proteins (HNPs), and that doxycycline can be used as treatment.
Methods: In this randomised, double-blind, placebo-controlled, phase 2 trial, we recruited participants from districts affected by nodding syndrome in northern Uganda.
Serotonin 2C receptor in a rat model of temporal lobe epilepsy: From brainstem expression to pharmacological blockade in relation to ventilatory function.
Epilepsia
July 2024
Lyon Neuroscience Research Center, Inserm U1028, CNRS UMR5292, Lyon 1 University, Lyon, France.
Because of its involvement in breathing control and neuronal excitability, dysregulation of the serotonin (5-HT) 2C receptor (5-HT2C) might play a key role in sudden unexpected death in epilepsy. Seizure-induced respiratory arrest is thus prevented by a 5-HT2B/C agonist in different seizure model. However, the specific contribution of 5-HT2C in chronic epilepsy-related respiratory dysfunction remains unknown.
View Article and Find Full Text PDFAge-Dependent Activation of Pannexin1 Function Contributes to the Development of Epileptogenesis in Autosomal Dominant Sleep-related Hypermotor Epilepsy Model Rats.
Int J Mol Sci
January 2024
Department of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.
To explore the processes of epileptogenesis/ictogenesis, this study determined the age-dependent development of the functional abnormalities in astroglial transmission associated with pannexin1-hemichannel using a genetic rat model of autosomal dominant sleep-related hypermotor epilepsy (ADSHE) named 'S286L-TG'. Pannexin1 expression in the plasma membrane of primary cultured cortical astrocytes and the orbitofrontal cortex (OFC), which is an ADSHE focus region, were determined using capillary immunoblotting. Astroglial D-serine releases induced by artificial high-frequency oscillation (HFO)-evoked stimulation, the removal of extracellular Ca, and the P2X7 receptor agonist (BzATP) were determined using ultra-high performance liquid chromatography (UHPLC).
View Article and Find Full Text PDFCGRP monoclonal antibodies and CGRP receptor antagonists (Gepants) in migraine prevention.
Handb Clin Neurol
February 2024
Headache and Neurological Pain Research Group, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain; Headache Unit, Neurology Department, Hospital Universitario Vall d'Hebron, Barcelona, Spain. Electronic address:
Article Synopsis
- Migraine is a common and debilitating neurological condition with historically limited preventive treatment options due to a lack of effective therapies.
- Recent research has identified calcitonin gene-related peptide (CGRP), a crucial player in migraine, leading to the development of targeted treatments such as anti-CGRP monoclonal antibodies and gepants.
- Four monoclonal antibodies (erenumab, galcanezumab, fremanezumab, and eptinezumab) and two gepants (rimegepant and atogepant) have been approved, showing promising results for preventing both episodic and chronic migraines.
Low glycemic index diet restrains epileptogenesis in a gender-specific fashion.
Cell Mol Life Sci
November 2023
Department of Experimental Medicine, University of Genova, Genoa, Italy.
Dietary restriction, such as low glycemic index diet (LGID), have been successfully used to treat drug-resistant epilepsy. However, if such diet could also counteract antiepileptogenesis is still unclear. Here, we investigated whether the administration of LGID during the latent pre-epileptic period, prevents or delays the appearance of the overt epileptic phenotype.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!