In this column, Dr Reid-Ponte interviews Dr Karen Cox, current president of the American Academy of Nursing and chief operating officer for Children's Mercy Hospital in Kansas City. Dr Cox discusses her leadership trajectory and lessons learned.
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| http://dx.doi.org/10.1097/NNA.0000000000000641 | DOI Listing |
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Accurately estimating effective population size ( ) is essential for understanding evolutionary processes and guiding conservation efforts. This study investigates estimation methods in spatially structured populations using a population of moor frog () as a case study. We assessed the behaviour of estimates derived from the linkage disequilibrium (LD) method as we changed the spatial configuration of samples.
View Article and Find Full Text PDFAbatacept Pharmacokinetics and Exposure Response in Patients Hospitalized With COVID-19: A Secondary Analysis of the ACTIV-1 IM Randomized Clinical Trial.
JAMA Netw Open
April 2024
Duke Clinical Research Institute, Durham, North Carolina.
Importance: The pharmacokinetics of abatacept and the association between abatacept exposure and outcomes in patients with severe COVID-19 are unknown.
Objective: To characterize abatacept pharmacokinetics, relate drug exposure with clinical outcomes, and evaluate the need for dosage adjustments.
Design, Setting, And Participants: This study is a secondary analysis of data from the ACTIV-1 (Accelerating COVID-19 Therapeutic Interventions and Vaccines) Immune Modulator (IM) randomized clinical trial conducted between October 16, 2020, and December 31, 2021.
Genome-wide methylome stability and parental effects in the worldwide distributed Lombardy poplar.
BMC Biol
February 2024
Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium.
Background: Despite the increasing number of epigenomic studies in plants, little is known about the forces that shape the methylome in long-lived woody perennials. The Lombardy poplar offers an ideal opportunity to investigate the impact of the individual environmental history of trees on the methylome.
Results: We present the results of three interconnected experiments on Lombardy poplar.
Importance: Immune dysregulation contributes to poorer outcomes in COVID-19.
Objective: To investigate whether abatacept, cenicriviroc, or infliximab provides benefit when added to standard care for COVID-19 pneumonia.
Design, Setting, And Participants: Randomized, double-masked, placebo-controlled clinical trial using a master protocol to investigate immunomodulators added to standard care for treatment of participants hospitalized with COVID-19 pneumonia.
Background: Institutions may be experiencing an increasing number of applicants who are underprepared for nursing study, especially institutions with access missions. Early identification and intervention can mitigate risk of attrition and unsuccessful NCLEX-RN outcomes.
Method: An initial study of approximately 1,500 graduates from a multi-campus system led to the development of a comprehensive approach to student success.
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