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A real-world disproportionality analysis of colchicine: data mining of the public version of FDA Adverse Event Reporting System.
Expert Opin Drug Saf
December 2024
Department of Cardiology, Intervention Cardiology Center, Wuhan No.1 Hospital, Wuhan, China.
Background: Colchicine is widely used for gout and familial Mediterranean fever (FMF) and has cardiovascular benefits. However, it is linked to various adverse drug reactions (ADRs). This study aimed to analyze colchicine-related ADRs using FAERS data for safer clinical use.
View Article and Find Full Text PDFChanges in Red Cell Morphology and Haematological Laboratory Parameters Associated With Alectinib.
J Clin Lab Anal
July 2024
Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
Background: Alectinib is a second-generation anaplastic lymphoma kinase (ALK) inhibitor indicated for ALK-mutated non-small-cell lung cancer. Recently, the association between alectinib and red cell morphological abnormalities has been reported in a few case series. This retrospective observational study aims to determine the frequency of occurrence of acanthocytosis in patients taking alectinib and to evaluate the red cell indices, biochemical markers of haemolysis and eosin-5-maleimide (EMA) binding assay results in patients receiving alectinib.
View Article and Find Full Text PDFA Systemic Review of the Psychosocial Aspects of Chronic Pain in Youth With Sickle Cell Disease.
Pain Manag Nurs
June 2024
University of Connecticut, School of Nursing, Storrs, Connecticut.
Objectives: The psychosocial aspects of chronic pain among youth with sickle cell are poorly described and may be better understood within a biopsychosocial model of chronic pain as applied to youth living with sickle cell disease.
Design: A systematic literature review was performed to synthesize the psychosocial factors contributing to chronic pain in this population. Criteria for study inclusion were primary quantitative research studies focused on psychosocial aspects of chronic pain among youth with sickle cell disease.
Red cell abnormalities characterized by ektacytometry in children with cholestasis.
Pediatr Res
March 2024
Division of Pediatric Gastroenterology, Hepatology, and Nutrition Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.
Background: Spur-cell anemia sometimes accompanies cholestasis. We postulated that even in the absence of spur-cells, cholestasis might alter red blood cell (RBC) osmotic fragility and deformability. Therefore, we assessed these RBC measures by ektacytometry in pediatric patients.
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