Herein, we report a novel intramolecular ring-closing reaction of biaryl thioethers that give access to highly functionalized dibenzothiophene sulfonium salts under mild conditions. The resulting precursors react regioselectively with [F]fluoride to give [F]fluoroarenes in predictable radiochemical yields. The strategy expands the available radiochemical space and provides superior labeling efficiency for clinically relevant PET tracers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128620 | PMC |
| http://dx.doi.org/10.1021/jacs.8b06730 | DOI Listing |
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