[Effects of Scrophulariae Radix and Split Component on Isoproterenol-Induced Ventricular Remodeling in Rat].

Objective: To explore the effects and mechanism of Scrophulariae Radix and split component on experimental ventricular remodeling.

Methods: The rats were injected subcutaneously by 10,5 mg / kg ISO for 2 d and then 3 mg / kg ISO as maintenance dose for 7 d to build the the ventricular remodeling. After 21 days’ treatment,the left ventricular mass index( LVMI) and heart mass index( HMI) were measured. The content of atrial natriuretic peptide( ANP),endothelin-1( ET-1) and angiotensinⅡ( Ang II) were determined by enzyme linked immunosorbent assay( ELISA),and the pathological changes of myocardial tissue were also observed.

Results: LVMI,HMI were improved by total composition components and small polar iridoid glycosides components,and the content of ANP,ET-1 and AngⅡwas decreased remarkably; The polysaccharide components could only decline the content of Ang Ⅱ and ET-1.

Conclusion: The pharmacological effects of Scrophulariae Radix inhibit ventricular remodeling may be related to the small polar iridoid glycosides components and the polysaccharide components. And the mechanism may be related to regulating the over expression neurohumor factors and inhibiting the release of ANP and ET-1,Ang Ⅱ.