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Currently in wheat breeding, genome wide association studies (GWAS) have successfully revealed the genetic basis of complex traits such as nitrogen use efficiency (NUE) and its biological processes. In the GWAS model, thresholding is common strategy to indicate deviation of expected range of -(s), and it can be used to find the distribution of true positive associations under or over of test statistics. Therefore, the threshold plays a critical role to identify reliable and significant associations in wide genome, while the proportion of false positive results is relatively low.
View Article and Find Full Text PDFPredictive models are indeed useful for causal inference.
Ecology
January 2025
Department of Natural Resources and the Environment, Cornell University, Ithaca, New York, USA.
The subject of investigating causation in ecology has been widely discussed in recent years, especially by advocates of a structural causal model (SCM) approach. Some of these advocates have criticized the use of predictive models and model selection for drawing inferences about causation. We argue that the comparison of model-based predictions with observations is a key step in hypothetico-deductive (H-D) science and remains a valid approach for assessing causation.
View Article and Find Full Text PDFContribution of type 2 diabetes to major adverse cardiovascular events (MACE) in a long-term observational study with different stages of atherosclerosis.
Sci Rep
January 2025
VIVIT-Institute, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.
The impact of diabetes on incident cardiovascular disease in relation to the extent of atherosclerotic disease remains unclear. We aimed to investigate major adverse cardiovascular events (MACE) in patients with or without type 2 diabetes (T2DM) presenting with two extremes of atherosclerotic disease, those with angiographically documented minor coronary atherosclerotic lesions and those with symptomatic peripheral artery disease. We included 1238 patients from two prospective, long-term cohort studies.
View Article and Find Full Text PDFPost-traumatic stress disorder (PTSD) symptom clusters associated with an indicator of heart rate variability: The ADVANCE cohort study.
J Affect Disord
January 2025
King's Centre for Military Health Research, King's College London, SE5 9RJ, United Kingdom of Great Britain and Northern Ireland; Academic Department of Military Mental Health, King's College London, SE5 9RJ, United Kingdom of Great Britain and Northern Ireland.
Background: Heart rate variability (HRV) is governed by of sympathetic and parasympathetic regulatory systems. Post-Traumatic Stress Disorder (PTSD) may influence these systems and consequently affect cardiovascular functioning.
Methods: The sample consisted of 860 UK male military personnel approximately half of who had sustained physical combat injuries in Afghanistan.
Efficacy of an intervention to increase therapeutic adherence in patients with secondary prevention for cardiovascular disease: a study protocol for a randomized controlled trial.
Front Med (Lausanne)
January 2025
Department of Clinical Medicine, Miguel Hernández University of Elche, San Juan de Alicante, Spain.
Introduction: Cardiovascular diseases represent the leading cause of mortality worldwide. This category includes cerebrovascular disease, ischemic heart disease, and peripheral vascular disease. Secondary prevention is effective for patients with a history of cardiovascular events, with antihypertensives, statins, and acetylsalicylic acid being the most prescribed drugs.
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