Objective: To investigate the chemical constituents of Thalictrum fortunei.
Methods: Compounds were separated and purified by chromatographic methods and the structures were identified by their physicochemical properties and spectroscopic data.
Results: Ten compounds were isolated and identified as bergenin( 1),1-( 4-hydroxy-3-methoxy)-phenyl-2-[4-( 1,2,3-trihydroxypropyl)-2-methoxy]-phenoxym-1,3-propandiol( 2) 、4-( 2-hydroxyethyl)-2-methoxyphenyl-O-β-D-glucopyranoside( 3),meliasendanin D( 4),2-( 4-hydroxy-3-methoxyphenyl)-ethyl-O-β-D-glucopyranoside( 5),kizutasaponin C( 6),2-( 3-hydroxy-4-methoxyphenyl)-ethyl-O-β-Dglucopyranoside( 7),β-sitosterol( 8),3-O-β-D-glucopyranosyl( 1→6)-β-D-glucopyranosyl( 22 S,24Z)-cycloart-24-en-3β,22,30-tetraol-26-O-β-D-glucopyranoside( 9) and 3-O-β-D-quinovopyranosyl( 1→6)-β-D-glucopyranosyl( 1→4)-β-D-fucopyranosyl( 22 S,24Z)-cycloart-24-en-3β,22,26-triaol-26-O-β-D-glucopyranoside( 10).
Conclusion: Compounds 1 ~ 6 are isolated form this plant for the first time.
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J Exp Pharmacol
February 2023
School of Pharmacy and Laboratory of Drug Quality (JuLaDQ), Jimma University, Jimma, Oromia, Ethiopia.
Background: The emergence and spread of resistant microbes continue to be a major public health concern. Effective treatment alternatives, particularly from traditionally used medicinal plants, are needed.
Objective: The main objective of this study was to conduct phytochemical screening and antimicrobial activity evaluation of selected traditionally used medicinal plants in Ethiopia.
J Ethnopharmacol
April 2023
Angiosperm Taxonomy Laboratory, Department of Botany, Shivaji University, Kolhapur 416 004, Maharashtra, India.
Ethnopharmacological Relevance: Thalictrum (Ranunculaceae) is known for its important alkaloids which have been reported to exhibit various pharmacological activities, viz. antitumor, antimicrobial, antitussive, antiamebic, hypotensive effects, HIV antiviral, etc. Throughout the world, the plant has been used as a tonic, purgative, stimulant, aperient and is utilized in various systems of medicine in the treatment of various ailments like snake bite, jaundice, rheumatism, stomachache, wounds, swellings, uterine tumors, paralysis, joints pain, nervous disorders, toothache, diarrhea, piles, fever, peptic ulcer, ophthalmic, headache, diuretic, dyspepsia, convalescence, etc.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
May 2022
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University Shenyang 110016, China.
The chemical constituents from the roots of Thalictrum cultratum and T. baicalense were investigated. By various isolation methods, such as silica gel, aluminium oxide, ODS, and Sephadex LH-20 column chromatographies, and semi-preparative HPLC, 11 simple isoquinoline alkaloids were isolated from the ethanol extract of the roots of these two plants, including a new compound, named dehydrothalflavine(1), and ten known ones(2-11): N-methylcorydaline(2), N-methylthalidaldine(3), thaliflavine(4), oxyhydrastinine(5), noroxyhydrastinine(6), dimethoxyisoquinolone(7), thalactamine(8), dehydronoroxyhydrastinine(9), 6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline(10), and isopicnarrhine(11).
View Article and Find Full Text PDFFront Plant Sci
May 2022
Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
is a phylogenetically and economically important genus in the family Ranunculaceae, but is also regarded as one of the most challengingly difficult in plants for resolving the taxonomical and phylogenetical relationships of constituent taxa within this genus. Here, we sequenced the complete plastid genomes of two species using Illumina sequencing technology assembly. The two plastomes exhibited circular and typical quadripartite structure that was rather conserved in overall structure and the synteny of gene order.
View Article and Find Full Text PDFJ Pharm Biomed Anal
July 2017
School of Pharmacy, China Medical University, Shenyang 110001, PR China. Electronic address:
Hernandezine, a novel anticancer AMPK activator, is a major active constituent of Thalictrum Ranunculaceae. A simple, specific and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the quantification of hernandezine in rat plasma and tissues after intravenous administration. Sample preparation was carried out through a protein-precipitation extraction with acetonitrile using tetrandrine as internal standard (IS).
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