Objective: To explore the chemical constituents of Ranunculus ternatus and their inhibitory effects on multidrug-resistant tuberculosis.
Methods: All compounds were separated by silica gel, Sephadex LH-20 column chromatography etc. Their structures were identified by NMR spectroscopy. The absolute concentration method was used for susceptibility test on multidrug-resistant tuberculosis strains with Ranunculus ternatus.
Results: Seven compounds were isolated and identified as 2-deoxy-D-ribono-1,4-lactone( 1),isomaltol-α-D-glucoside( 2),vanillic acid-4-O-β-D-glucopyranoside( 3), salicoside( 4),n-butyl-β-D-fructofuranoside( 5),3,4-dimethoxybenzoic acid( 6),and caffeic acid( 7).
Conclusion: Compounds 1 ~ 6 are isolated from this genus for the first time. All compounds except 5 of Ranunculus ternatus reveal modest activity to inhibit multidrug-resistant tuberculosis.
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