Study Design: Observational study.
Objectives: To characterize the cardiorespiratory and metabolic response of elite wheelchair racing (WCR) athletes during a 25 km, field-based time trial.
Settings: University laboratory and field racing course in Urbana, Illinois, USA.
Methods: Seven elite WCR athletes (4 men/3 women) with spinal cord injury completed an incremental exercise test to exhaustion on a computerized wheelchair roller system to determine peak cardiorespiratory capacity in the laboratory. The athletes then completed a long-distance, field-based time trial (i.e., 25 km) within 5 days. Energy expenditure was measured continuously during the time trial with a portable metabolic unit. Blood samples were collected to determine blood lactate and glucose concentrations. Core temperature was measured using an ingestible sensor thermistor.
Results: Five participants completed the long-distance time trial with usable cardiorespiratory data. Median heart rate and oxygen consumption during the time trial was 93.6% and 76.6% of peak values, respectively. Median energy expenditure was 504.6 kcal/h. There was a significant increase in blood lactate concentration from 0.7 to 4.0 mmol/L after the time trial ( = 0.03). There were no changes in blood glucose concentrations after the time trial ( = 0.27). Lastly, core temperature significantly increased from 37.1 at baseline to 38.7 °C immediately after the time trial ( = 0.01).
Conclusions: Elite WCR athletes sustained a high exercise intensity that was consistent across the long-distance time trial, and exercise intensity outcomes were generally lower than those documented for elite able-bodied long-distance athletes in other studies. Our findings provide accurate estimates of energy expenditure that can be used to design effective training and racing strategies for elite WCR athletes.
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http://dx.doi.org/10.1038/s41394-018-0114-3 | DOI Listing |
Front Psychol
December 2024
Department of Psychology, University of Oslo, Oslo, Norway.
Introduction: When a child has a disability, their families face significant challenges that also impact parents' and siblings' mental health and adjustment. We examined the potential bidirectional relationships between parental mental health and sibling mental health and adjustment in families of children with a disability.
Methods: We utilized baseline and 12-month follow-up data from a randomized controlled trial of a brief intervention designed to enhance parent-sibling communication in families of children with a disability.
Front Immunol
December 2024
Molecular Immunology and Gene Therapy, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Generation of high avidity T cell receptors (TCRs) reactive to tumor-associated antigens (TAA) is impaired by tolerance mechanisms, which is an obstacle to effective T cell therapies for cancer treatment. NY-ESO-1, a human cancer-testis antigen, represents an attractive target for such therapies due to its broad expression in different cancer types and the restricted expression in normal tissues. Utilizing transgenic mice with a diverse human TCR repertoire, we isolated effective TCRs against NY-ESO-1 restricted to HLA-A*02:01.
View Article and Find Full Text PDFJ Pain Res
January 2025
Department of Anesthesiology, the Second People's Hospital of Wuhu, Wuhu, Anhui, 241000, People's Republic of China.
Background: The erector spinae plane block (ESPB) has been increasingly utilized for postoperative analgesia in thoracic, abdominal, and spinal surgeries. This study evaluated the postoperative analgesic outcomes of ESPB with nalbuphine as a ropivacaine adjuvant for lumbar trauma surgery.
Methods: This randomized double-blind clinical trial included 57 participants who underwent lumbar trauma surgery.
Cureus
December 2024
College of Nursing, Kanto Gakuin University, Yokohama, JPN.
High-flow nasal oxygen therapy (HFNO) is highly versatile and employed in varied situations, including after extubation, in cases of respiratory failure, and at the end of life. However, its impact on swallowing function is not yet elucidated. Therefore, this scoping review aimed to clarify how HFNO affects swallowing function and whether it poses a risk for aspiration pneumonia.
View Article and Find Full Text PDFCureus
December 2024
Obstetrics and Gynecology, Duhok Obstetrics and Gynecology Teaching Hospital, Duhok, IRQ.
Aims: To determine the effectiveness of tranexamic acid (TXA) in reducing vaginal bleeding, extending pregnancy duration, and enhancing perinatal outcomes in pregnant women with placenta previa.
Methods: A multicenter, randomized, double-blind clinical trial was conducted at three maternity teaching hospitals in Iraq's Kurdistan region, Azadi Hospital in the north of Iraq, and Al-Azhar University Hospital in Egypt on 146 women with placenta previa. Participants were randomly assigned to two interventional groups in a 1:1 ratio to receive either TXA or Dextrose 5% water (D5W).
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