A phosphine-catalyzed reaction between o-hydroxyaryl azomethine ylides and MBH carbonates provides access to highly functionalized γ-aminobutyric acid derivatives in moderate to good yields. Mechanistically, the reaction involves a phosphine-catalyzed tandem S2'/2-aza-Cope rearrangement/intramolecular addition process.
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| http://dx.doi.org/10.1021/acs.orglett.8b02297 | DOI Listing |
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