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Assessment of Geriatric Problems and Risk Factors for Delirium in Surgical Medicine: Protocol for Multidisciplinary Prospective Clinical Study.
JMIR Res Protoc
January 2025
Orthopedics and Trauma Surgery, University Hospital Düsseldorf, Düsseldorf, Germany.
Background: An aging population in combination with more gentle and less stressful surgical procedures leads to an increased number of operations on older patients. This collectively raises novel challenges due to higher age heavily impacting treatment. A major problem, emerging in up to 50% of cases, is perioperative delirium.
View Article and Find Full Text PDFPolypharmacy and anticholinergic burden scales in older adults: a cross-sectional study among psychiatric outpatients in a tertiary care hospital.
BMC Geriatr
January 2025
Department of Orthopaedics, Kasturba Medical College, Manipal, Karnataka, 576104, India.
Introduction: Mental disorders are prevalent among older adults, often leading to the use of multiple medications, many with anticholinergic properties. Polypharmacy, common in this population, is a major contributor to anticholinergic burden, which is linked to cognitive and physical decline. This study investigates the relationship between polypharmacy and anticholinergic burden across seven anticholinergic burden scales in elderly patients attending the psychiatric outpatient.
View Article and Find Full Text PDF[Anticholinergic burden in the elderly].
Farm Comunitarios
January 2025
Farmacéutica comunitaria en Ferrol (La Coruña) España.
Anticholinergic drugs are widely used for very common diseases such as Parkinson's disease, depression or allergies, but it has been observed in previous studies that high anticholinergic burden can lead to physical and cognitive dysfunctions in polymedicated elderly people. The objective of this project is to review these hypotheses and study the possible relationship between high anticholinergic burden and cognitive and physical dysfunctions.In terms of methodology, a bibliographic review has been carried out of the information that exists to date on the hypothesis that high anticholinergic burden can lead to both physical and cognitive dysfunctions in elderly people taking multiple medications, and a cross-sectional study has been designed that included patients over 70 years and taking multiple medications to calculate the anticholinergic burden of their medication and determine whether high levels of it could have any influence on the deterioration of the patients.
View Article and Find Full Text PDFImpact of Anticholinergic Burden on Cognitive Functions in Individuals with Bipolar Disorder, Schizoaffective Disorder, and Schizophrenia.
Clin Psychopharmacol Neurosci
February 2025
Department of Psychiatry, Pamukkale University, Denizli, Türkiye.
Objective: Bipolar disorder (BD), schizoaffective disorder (SAD), and schizophrenia (SCH) are psychiatric disorders characterized by persistent cognitive impairments, even during periods of remission. Psychotropic medications commonly used to manage these conditions have anticholinergic properties, which may contribute to cognitive impairment.
Methods: This study examined the relationship between anticholinergic medication burden and cognitive function in individuals diagnosed with BD, SAD, and SCH.
Correction: Anticholinergic Exposure, Drug Dose and Postoperative Delirium: Comparison of Dose-Related and Non-Dose-Related Anticholinergic Burden Scores in a Retrospective Cohort Study of Older Orthopaedic and Trauma Surgery Patients.
Drugs Aging
January 2025
Hospital Pharmacy, LMU University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.
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