Bowenoid papulosis is a new and rather frequent entity affecting young men and women. Clinically, the lesions consists of multiple red or brown papules in the genitoanal region. Histologically, the papules shows alterations of the epidermis similar to those in Bowen's disease. The course of the disease, however, is benign. Recent investigations by zur Hausen, Ikenberg et al. have demonstrated the presence of HPV type 16-DNA in bowenoid papulosis.
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Vulvar Epidermolytic Hyperkeratosis: A Comprehensive Systematic Review of Case Reports and Series.
J Clin Med
December 2024
Department of Oncologic Dermatology-Elias Emergency University Hospital, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
: Vulvar epidermolytic hyperkeratosis (EHK) is an exceedingly rare dermatological condition, often presenting as solitary or multiple lesions in the vulvar region. Due to its clinical resemblance to other vulvar disorders, such as condyloma acuminatum, Bowenoid papulosis, and squamous cell carcinoma, vulvar EHK poses significant diagnostic challenges. While individual case reports and small case series have documented instances of vulvar EHK, comprehensive studies systematically consolidating the clinical, histopathological, and therapeutic aspects of this condition remain lacking.
View Article and Find Full Text PDFArticle Synopsis
- The article presents a clinical case of a young patient with HPV-associated penile intraepithelial neoplasia (PIN), specifically the erythematous form of bowenoid papulosis.
- It highlights the issues of delayed diagnosis due to improper diagnostic approaches and a lack of awareness among doctors about cancer-related diseases.
- The piece emphasizes the significance of early detection in preventing progression to more severe conditions like squamous cell penile carcinoma, detailing the different subtypes of PIN and their varying risks of leading to cancer.
The combination of holmium laser and ALA-PDT for Bowenoid Papulosis with diffuse large B-cell lymphoma.
Photodiagnosis Photodyn Ther
February 2024
Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China. Electronic address:
Article Synopsis
- Bowenoid Papulosis (BP) is a pre-cancerous condition that affects the anogenital area and can become serious if combined with immunosuppression, leading to potential complications like squamous cell carcinoma.
- A complex case involving BP, Bowen's disease, and Diffuse Large B-Cell Lymphoma was treated successfully using a combination of holmium laser therapy and 5-Aminolevulinic Acid Photodynamic Therapy (ALA-PDT).
- After treatment, the lesion completely disappeared and there was no recurrence of the affected area for five years.
Clinical and histopathological characteristics, diagnosis and treatment, and comorbidities of Bowen's disease: a retrospective study.
Front Med (Lausanne)
November 2023
Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
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- Bowen's disease (BD) is a precancerous skin condition that often gets misdiagnosed due to similarity with other skin diseases, with a study showing a diagnosis accuracy of just 54%.
- A retrospective study of 50 patients revealed that the average onset age was 55.1 for males and 58.2 for females, with the disease duration averaging 25.3 months for males and 33.9 months for females, but there were no significant differences based on gender.
- The study also found that 66% of BD patients had other health conditions, with skin diseases being the most common comorbidity, while the majority of cases showed signs of squamous-cell hyperplasia and other atypical cellular characteristics
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