The activity of SDG, Na, K-ATPase and Mg-ATPase of the grass frog was determined in January, March and May, the number of animals examined being 30-40 in either series of experiments. In May (period of reproduction) the average activity of the above enzymes was higher than in January and March. This was observed both in males and females. A correlation between enzymatic activities of each single organism in March and May significantly increased. The role of these changes in the increase of viability of the organism is discussed.

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