deletion fails to rescue premature lethality in two models of sodium channel epilepsy.

Deletion of , encoding the microtubule-binding protein Tau, prevents disease in multiple genetic models of hyperexcitability. To investigate whether the effect of Tau depletion is generalizable across multiple sodium channel gene-linked models of epilepsy, we examined the mouse model of Dravet syndrome, and the model of Early Infantile Epileptic Encephalopathy. Both models display severe seizures and early mortality. We found no prolongation of survival between , or mice or between , , or mice. Thus, the effect of deletion on mortality in epileptic encephalopathy models is gene specific and provides further mechanistic insight.