This report deals with the analysis of a cryocooler as a linear dynamical system around a set point, over a range of temperatures where the thermal properties can be considered constant. The accurate knowledge of the cryocooler temperature dependence with a time dependent power stimulus allows to analyze the thermodynamical properties of the system and understand the power flow related, for example, to the cryocooler temperature fluctuations. This is useful for the design of efficient thermal dampers that are necessary for the thermal stabilization of the device under test Sosso et al. [1], Trinchera et al. [2]. Two different and independent methods for deriving the cooler dynamic (i.e. non-stationary) behavior are described using the two main approaches to mathematically represent a dynamical system: step response and transfer function. •Using both approaches we were able to cross check results and provide an estimate of the accuracy of each method.•The instrumentation required is typically available in physics and engineering laboratories.•These results provide insights on cryocooler thermodynamics and design tools for cryocooler engineering.
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http://dx.doi.org/10.1016/j.mex.2018.06.013 | DOI Listing |
JMIR Res Protoc
January 2025
Data and Web Science Group, School of Business Informatics and Mathematics, University of Manneim, Mannheim, Germany.
Background: The rapid evolution of large language models (LLMs), such as Bidirectional Encoder Representations from Transformers (BERT; Google) and GPT (OpenAI), has introduced significant advancements in natural language processing. These models are increasingly integrated into various applications, including mental health support. However, the credibility of LLMs in providing reliable and explainable mental health information and support remains underexplored.
View Article and Find Full Text PDFBackground And Aim: There is paucity of data about the prevalence of cirrhosis and portal hypertension in the US general population.
Methods: We used National Health and Nutrition Examination Surveys (NHANES 2017-2020) to estimate the prevalence of cirrhosis and clinically significant (CS)-portal hypertension in alcoholic liver disease (ALD), MetALD, viral hepatitis (VH) to include chronic hepatitis B (CHB) and chronic hepatitis C (CHC), and metabolic dysfunction-associated steatotic liver disease (MASLD). Cirrhosis was evaluated using liver stiffness measurement (LSM) by transient elastography or FIB-4 score; CS-portal hypertension was defined via LSM and platelet count or the use of non-selective beta-blockers in the presence of cirrhosis.
J Clin Oncol
January 2025
Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Chinese University of China, Shatin, Hong Kong Special Administrative Region, China.
Purpose: Mobocertinib is an oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that targets exon 20 insertion (ex20ins) mutations in non-small cell lung cancer (NSCLC). This open-label, phase III trial (EXCLAIM-2: ClinicalTrials.gov identifier: NCT04129502) compared mobocertinib versus platinum-based chemotherapy as first-line treatment of ex20ins+ advanced/metastatic NSCLC.
View Article and Find Full Text PDFNeurology
February 2025
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Background And Objectives: Lipid metabolism in older adults is affected by various factors including biological aging, functional decline, reduced physiologic reserve, and nutrient intake. The dysregulation of lipid metabolism could adversely affect brain health. This study investigated the association between year-to-year intraindividual lipid variability and subsequent risk of cognitive decline and dementia in community-dwelling older adults.
View Article and Find Full Text PDFJ Am Coll Health
January 2025
Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada.
Introduction: Undergraduate students face a multitude of unique stressors which can affect their mental health and well-being. Finding ways to promote positive mental health among students is critical. Engagement in prosocial behavior is one way to buffer against such negative mental health outcomes.
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