Bisalbuminemia: A Rare Finding on Serum Electrophoresis.

Indian J Hematol Blood Transfus

Department of Laboratory Medicine, Rajiv Gandhi Cancer Institute and Research Center, Rohini, Delhi India.

Published: July 2018

Bisalbuminemia is an uncommon finding that is seen as bifid albumin peak on serum protein electrophoresis. We report here this unusual finding in an adult male diagnosed with multiple myeloma on routine workup.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081336PMC
http://dx.doi.org/10.1007/s12288-017-0911-zDOI Listing

Publication Analysis

Top Keywords

bisalbuminemia rare
4
rare finding
4
finding serum
4
serum electrophoresis
4
electrophoresis bisalbuminemia
4
bisalbuminemia uncommon
4
uncommon finding
4
finding bifid
4
bifid albumin
4
albumin peak
4

Similar Publications

Bisalbuminemia is a rare, typically benign condition marked by the presence of a bifid albumin band on serum protein electrophoresis. It can either be inherited due to a point mutation or acquired in association with various medical conditions, most commonly diabetes mellitus. Bisalbuminuria, the presence of bifid albumin in urine, may or may not accompany bisalbuminemia.

View Article and Find Full Text PDF

Bisalbuminemia is a rare, benign, protein anomaly presenting with two distinct peaks of albumin on serum protein electrophoresis. It reflects the presence of a normal albumin and a modified albumin in the same individual. This condition can be either hereditary or acquired.

View Article and Find Full Text PDF
Article Synopsis
  • Bisalbuminemia and bisalbuminuria are rare conditions where abnormal albumin bands are found in serum and urine, typically discovered during screenings for other health issues, with a prevalence of 1 in 1,000 to 1 in 10,000.
  • The reported case involved two adult male diabetic patients, one with rheumatoid arthritis and potential Sjogren syndrome, exhibiting both bisalbuminemia and bisalbuminuria, while the other had chronic kidney disease and exhibited bisalbuminemia only.
  • These conditions may arise from genetic variants or be acquired, often associated with diabetes, and while many cases are harmless, some albumin variants can affect how the body handles certain hormones and medications, potentially leading to significant health
View Article and Find Full Text PDF

The human albumin gene, the most abundant serum protein, is located in the long arm of chromosome 4, near the centromere, position 4q11-3. It is divided by 14 intervening introns into 15 exons, the last of which is untranslated. To date, 74 nucleotide substitutions (mainly missense) have been reported, determining the circulating variants of albumin or pre-albumin.

View Article and Find Full Text PDF

The incidence of a bifid electrophoretic pattern in the albumin region on serum protein electrophoresis is an infrequent phenomenon. The availability of literature from India is scarce and is limited to case reports. The aim of the study is to analyze the frequency of bisalbuminemia in an Indian referral facility.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!