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Polyploid giant cancer cells: origin, possible pathways of formation, characteristics, and mechanisms of regulation.
Front Cell Dev Biol
July 2024
Laboratory of Basic Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning, China.
Polyploid giant cancer cells (PGCCs) are characterized by the presence of either a single enlarged nucleus or multiple nuclei and are closely associated with tumor progression and treatment resistance. These cells contribute significantly to cellular heterogeneity and can arise from various stressors, including radiation, chemotherapy, hypoxia, and environmental factors. The formation of PGCCs can occur through mechanisms such as endoreplication, cell fusion, cytokinesis failure, mitotic slippage, or cell cannibalism.
View Article and Find Full Text PDFNon-mitotic proliferation of malignant cancer cells revealed through live-cell imaging of primary and cell-line cultures.
Cell Div
February 2024
Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China.
Introduction: Anti-mitosis has been a key strategy of anti-cancer therapies, targeting at a fundamental property of cancer cells, their non-controllable proliferation due to overactive mitotic divisions. For improved anti-cancer therapies, it is important to find out whether cancer cells can proliferate independent of mitosis and become resistant to anti-mitotic agents.
Results: In this study, live-cell imaging was applied to both primary-cultures of tumor cells, and immortalized cancer cell lines, to detect aberrant proliferations.
Phosphoinositide species and filamentous actin formation mediate engulfment by senescent tumor cells.
PLoS Biol
October 2022
Tulane School of Medicine, Department of Biochemistry and Molecular Biology, New Orleans, Louisiana, United States of America.
Cancer cells survive chemotherapy and cause lethal relapse by entering a senescent state that facilitates expression of many phagocytosis/macrophage-related genes that engender a novel cannibalism phenotype. We used biosensors and live-cell imaging to reveal the basic steps and mechanisms of engulfment by senescent human and mouse tumor cells. We show filamentous actin in predator cells was localized to the prey cell throughout the process of engulfment.
View Article and Find Full Text PDFPolyploidy formation in cancer cells: How a Trojan horse is born.
Semin Cancer Biol
June 2022
Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine, Szaserow 128 Street, Warsaw, Poland.
Ploidy increase has been shown to occur in different type of tumors and participate in tumor initiation and resistance to the treatment. Polyploid giant cancer cells (PGCCs) are cells with multiple nuclei or a single giant nucleus containing multiple complete sets of chromosomes. The mechanism leading to formation of PGCCs may depend on: endoreplication, mitotic slippage, cytokinesis failure, cell fusion or cell cannibalism.
View Article and Find Full Text PDFPostchemotherapy erythroid cannibalism in relapsed NPM1, FLT3-mutated acute myeloid leukemia.
Int J Lab Hematol
April 2021
Department of Hematology, Sir Gangaram Hospital, New Delhi, India.
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