and Allele Frequencies Among Southern Thai Blood Donors.

Indian J Hematol Blood Transfus

4Graduate Program, Faculty of Allied Health Sciences, Thammasat University, Pathumtani, Thailand.

Published: July 2018

Diego (DI) blood group genotyping is clinically important in Asian populations. Data of Diego blood type among southern Thais is still unknown. This study aimed to report and allele frequencies in southern Thai blood donors and to estimate potential risk of Di incompatibility and alloimmunization in Thai populations. DNA samples obtained from 427 southern Thai blood donors were genotyped for and alleles by polymerase chain reaction with sequence-specific primer. and allele frequencies among southern Thais were 0.0047 and 0.9953. Their frequencies were similar to those among American Native, Italian, Filipino, Alaska Native/Aleut and Hawaiian/Pacific Islander populations; while, the frequencies significantly differed from central and northern Thai, Southeast Asian, Brazilian, Southern Brazilian, Brazilian Japanese descendants, Japanese, Han Chinese, Chinese, and Korean populations ( < 0.05). The Di incompatibility among southern Thais (0.93%) was lower than among central Thais (3.49%), corresponding to a significantly lower probability of Di alloimmunization ( < 0.05). This is the first report of and allele frequencies among southern Thais, which is beneficial for not only creating information for estimating risk of alloimmunization, but also providing antigen-negative red cell donors to prevent both alloimmunization and adverse transfusion reactions.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081316PMC
http://dx.doi.org/10.1007/s12288-017-0886-9DOI Listing

Publication Analysis

Top Keywords

allele frequencies
12
frequencies southern
12
southern thai
12
thai blood
12
blood donors
12
diego blood
8
southern thais
8
southern
6
thai
5
blood
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!